Experimental and clinical research of HIV-1 resistance in three AIDS patients who had experienced multiple regimens  

作　　者：LU Jun-feng LI Jue LI Han-ping LIU Si-yang ZHUANG Dao-ming LIU Yong-jian BAO Zuo-yi LI Lin WU Hao LI Jing-yun 

机构地区：[1]Beijing Youan Hospital, Capital Medical University, Beijing 100069, China [2]State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China

出　　处：《Chinese Medical Journal》2009年第6期752-754,共3页中华医学杂志（英文版）

摘　　要：Highly active antiretroviral therapy （HAART） for HIV/AIDS has efficiently controlled the progression of the disease, extended life expectancy and decreased HIV/AIDS related morbidity and mortality since the advent of HIV protease inhibitors in 1996.1 Recent emergence of HIV resistance has severely affected the efficacy of antiretroviral therapy. The prevalence of HIV resistance has been increasing from the usage of AZT. Studies in US indicated that the prevalence was approximately 50% in patients who had experienced antiretroviral therapy.2 Antiviral regimens based on resistance tests could efficiently decrease viral load, increase CD4 cell counts and significantly improve the efficacy of antiretroviral therapy.3 There are two methods commonly used to test HIV resistance at present： one is genotypic resistance assay which predict HIV resistance based on resistance mutations in the viral genome; the other is a phenotypic resistance assay which directly evaluates HIV resistance through analyzing drug sensitivity in vitro.Highly active antiretroviral therapy （HAART） for HIV/AIDS has efficiently controlled the progression of the disease, extended life expectancy and decreased HIV/AIDS related morbidity and mortality since the advent of HIV protease inhibitors in 1996.1 Recent emergence of HIV resistance has severely affected the efficacy of antiretroviral therapy. The prevalence of HIV resistance has been increasing from the usage of AZT. Studies in US indicated that the prevalence was approximately 50% in patients who had experienced antiretroviral therapy.2 Antiviral regimens based on resistance tests could efficiently decrease viral load, increase CD4 cell counts and significantly improve the efficacy of antiretroviral therapy.3 There are two methods commonly used to test HIV resistance at present： one is genotypic resistance assay which predict HIV resistance based on resistance mutations in the viral genome; the other is a phenotypic resistance assay which directly evaluates HIV resistance through analyzing drug sensitivity in vitro.

关 键 词：human immunodeficiency virus type 1 genotypic resistance phenotypic resistance multi-drug resistance 

分 类 号：R512.91[医药卫生—内科学]