AZ31镁合金的生物降解行为研究  

Study on Biodegradation Behavior of AZ31 Magnesium Alloy

作　　者：杨柯[1] 谭丽丽[1] 任伊宾[1] 张炳春[1] 张广道[2] 艾红军[2] 

机构地区：[1]中国科学院金属研究所,辽宁沈阳110016 [2]中国医科大学附属口腔医学院,辽宁沈阳110002

出　　处：《中国材料进展》2009年第2期26-30,共5页Materials China

基　　金：中国科学院知识创新工程重要方向项目资助(KGCXZ-YW-207)

摘　　要：研究了AZ31镁合金作为生物医用材料的体内外生物降解行为。初步分析了其作为可降解生物医用材料的可行性。体外浸泡实验结果表明,AZ31镁合金的降解行为与其所处环境有关,在Hank’s溶液中的降解速度较在0.9%NaCl溶液中低;经过热处理后的AZ31镁合金较铸态和锻态降低了点蚀发生倾向,降解速度更慢。体内植入实验结果表明,AZ31镁合金与动物不同组织接触,其降解速度不同,在骨髓腔内的降解速度更快。植入5周时,镁合金已发生降解,20周降解更为明显。降解过程中镁合金表面有Ca-P物质沉积,表面具有优异的生物活性,其降解产物主要通过尿液进行排泄。在表面制备Ca-P涂层可降低镁合金的降解速度。AZ31镁合金是一种具有良好应用前景的新型生物可降解医用植入材料。In this paper, the biodegradation behavior of AZ31 magnesium alloy was studied and its potential as a biodegradable medical material was also discussed. The immersion study in vitro showed that the degradation rate of AZ31 alloy was affected by the immersion environment, higher in 0. 9% NaCl solution than in Hank＇s solution; heat treatment decreased the pitting corrosion tendency as well as the degradation rate of AZ31 alloy. Implantation in vivo showed that the degradation rate of AZ31 alloy could be different if contacting with different tissue, the fastest in the marrow cavity. The degradation occurred in AZ31 alloy after implanted for 5 weeks in vivo, and more degradation could be found after 20 -week implantation. There were Ca - P depositions on the surface of AZ31 alloy during degradation, which could improve the bioactivity of AZ31 alloy. The degradation product of AZ31 alloy implanted in vivo could be excreted through urine. A Ca- P coating on AZ31 alloy could decrease the degradation rate of the alloy. Therefore AZ31 magnesium alloy is a potentially new type of biodegradable implantation material.

关 键 词：AZ31镁合金 生物降解行为 表面涂层 可降解植入材料 

分 类 号：TG146.22[一般工业技术—材料科学与工程]