关节软骨生化结构及其与力学性能关系研究进展  

Research advances in biochemical structure,biomechanical property and their relationship of articular cartilage

作　　者：晏丹[1] 周广东[1] 曹谊林[1] 

机构地区：[1]上海交通大学医学院第九人民医院整复外科上海市组织工程研究重点实验室,上海200011

出　　处：《上海交通大学学报（医学版）》2009年第3期341-345,共5页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家高技术研究发展计划("863"计划)(2006AA02A126);国家重点基础研究发展计划("973"计划)(2005CB522702);国家自然科学基金(30300353)~~

摘　　要：关节软骨缺损在临床很常见。由于血液供应差及应答创伤反应的未分化细胞群相对缺乏,软骨缺损很难自行修复。组织工程技术可将具有软骨形成潜能的细胞接种到生物可降解材料上形成细胞-支架三维复合物,该复合物在体外或体内可形成组织工程化软骨,有望解决软骨缺损修复这一临床难题。要构建具有完整结构和稳定功能的组织工程化软骨,必须深入了解软骨的形态结构、功能及其关系。文章就正常及组织工程化关节软骨的生化结构及其与生物力学性能的关系进行综述。Articular cartilage defects are commonly found in clinics. It is always a great challenge for the repair of cartilage defects due to the limited self-regeneration after injury. Tissue engineering,a newly emerging biotechnique to regenerate cartilage with chondrogenic potential cells and biodegradable scaffolds in vivo and in vitro,provides a promising method to solve the challenge in cartilage defects repair. To regenerate cartilage with favourable structure and function,it is essential to gain a deep insight into the biochemical structure,biomechanical property and their relationship of articular cartilage. This article gives an introduction to the biochemical structure,biomechanical property and their relationship of both native and tissue-engineered cartilage.

关 键 词：关节软骨 生物力学 生化结构 组织工程 

分 类 号：R318.08[医药卫生—生物医学工程]