骨科植入物表面抗感染修饰研究进展  

Research advances in surface modification of orthopaedic implants for anti-infection

作　　者：曹聪[1] 李宝娥[2] 刘宣勇[2] 董宇启[1] 

机构地区：[1]上海交通大学医学院仁济医院骨科,上海200127 [2]中科院上海硅酸盐研究所,上海200050

出　　处：《上海交通大学学报（医学版）》2009年第3期353-357,共5页Journal of Shanghai Jiao tong University:Medical Science

摘　　要：骨科植入物相关感染是临床常见的术后并发症。通常采用抗细菌初始黏附、表面主动抗菌和促进骨整合等表面修饰技术使植入物具备抗感染特性,以降低感染发生率。文章就骨科植入物相关感染的发生机制、特点以及植入物表面抗感染修饰策略的研究进展进行综述,为今后新型抗感染植入物的开发提供参考。Implant-related infection is a commonly occurred complication in orthopaedics. The surface modification methods frequently used for anti-infection of implant surface were minimizing bacteria adhesion,grafting antibacterial agents and improving osteointegration. The pathogenesis and characteristics of orthopaedic implant-related infection and the research advances in the surface modification of orthopaedic implants for anti-infection are described in this paper,providing a reference for the research of novel implants with anti-infection characteristics.

关 键 词：骨髓炎 植入物相关感染 生物膜 表面修饰 

分 类 号：R687.3[医药卫生—骨科学]