器官移植术后血脂升高危险因素的探讨  

Risk Factors for Hyperlipidemia in Organ Transplant Recipients

作　　者：陈立[1] 王珏[1] 高强[1] 郑虹[2] 王建[2] 

机构地区：[1]天津市第一中心医院检验科,300192 [2]天津市第一中心医院移植外科,300192

出　　处：《天津医药》2009年第3期170-172,共3页Tianjin Medical Journal

摘　　要：目的:分析器官移植受者高脂血症的发病率及其危险因素。方法:收集209例肝、肾移植术后1年复查的相关资料。以独立样本t检验比较移植组与性别、年龄相匹配对照组的血胆固醇和三酰甘油浓度的差别。以二项Logistic回归分析移植组高脂血症的危险因素,包括年龄、性别、体质量指数(BMI)、血糖、血胆红素、尿素、肌酐、激素使用及钙调剂类型。结果:移植组血液胆固醇和三酰甘油浓度较对照组升高,差异有统计学意义(P<0.01),发病率高于对照组(胆固醇:24.4%vs5.0%;三酰甘油:55.5%vs15.0%)。钙调素抑制剂种类(P<0.01)、血清肌酐浓度(P<0.01)和BM(IP<0.05)是高胆固醇血症的主要危险因素;激素使用(P<0.01)和年龄(P<0.05)是高三酰甘油血症的主要危险因素(P<0.05)。结论:为防止高脂血症应注意调整器官移植受者的免疫抑制剂的使用,减少肾损伤,调整饮食并适当运动。Objective： To investigate the morbidity and risk factors of hyperlipidemia in organ transplant recipients. Methods： Data of 209 cases of liver and renal transplant recipients were collected at about one year after the transplantation. Blood levels of cholesterol and triglyceride in transplant group were compared with those of an accordant gender and age control group by independent t test. The potential risk factors,like age, gender, current BMI, blood concentrations of glucose, bilirubin, urea, ereatinine and the usage of immunosuppression, were analyzed by the methods of binary logistic regression. Results： The blood levels of cholesterol and triglyceride were significantly elevated in transplant group than those of control group （P 〈 0.01 ）. The morbidity was much higher in transplant group than that of control group （TC ：24.4% vs 5.0% ; TG ：55.5% vs 15.0% ）. The kind of calcineurin inhibitor （P 〈 0.01 ）, serum creatinine concentration （P 〈 0.01 ） and BMI（P 〈 0.05）were the main risk factors for hypercholeststerolemia. The use of prednisone （P 〈 0.01 ） and age （P 〈 0.05 ） were the main risk factors of hypertriglyeeridemia in transplant group. Conclusion ： More attention must be paid to adjust the usage of immunosuppression, decrease renal damage ,be on diet and train properly for the prevention of hyperlipidemia in organ transplant recipients.

关 键 词：高脂血症 危险因素 肝移植 肾移植 回顾性研究 

分 类 号：R58[医药卫生—内分泌] R699.2[医药卫生—内科学]