Association of serum sodium concentration with coronary atherosclerosis in China： follow-up study  

作　　者：En-zhi JIA Zhen-xia XU Zhi-jian YANG Tie-bing ZHU Lian-sheng WANG Bo CHEN Ke-jiang CAO JunHUANG Wen-zhu MA Xiang LU 

机构地区：[1]Department of Cardiovascular Medicine, the first Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China [2]Department of cardiovascular medicine, the second affiliated hospital of Nanjing Medical University, Nanjing 210011, China

出　　处：《Acta Pharmacologica Sinica》2009年第4期494-500,共7页中国药理学报（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China （No 30400173）.

摘　　要：Aim： The aim of this study was to test the hypothesis that lower serum sodium may be associated with increased cardiovascular events and all-cause mortality by means of long-term follow-up of subjects with coronary atherosclerosis in a prospective, hospital-based epidemiological study in China. Methods： A prospective, hospital-based epidemiological design was used. The study population consisted of 1069 consecutive patients who were scheduled to undergo coronary angiography for suspected or known coronary atherosclerosis. The severity of coronary atherosclerosis was defined using Gensini＇s score system. Age, sex-adjusted hazard ratios （HR） and 95% confidence intervals （CI） for the quartiles of serum sodium concentration were estimated with Cox proportional hazard models, using quartile 1 as the reference. Cox proportional hazard models were also constructed to estimate the hazard ratios and 95% confidence intervals for all-cause mortality and final end-point events by serum sodium quartile and to adjust for potentially confounding variables. Multivariate models were adjusted for the following variables： age, sex, smoking status, alcohol consumption, body mass index, blood pressure, potassium, chloride, total cholesterol, triglycerides, fasting blood glucose, urea, creatinine, uric acid, and Gensini＇s score. Results： During the median 2.86 years （3011.66 person-years） of follow-up, 176 final end-point events were documented. These events included 79 deaths and 97 readmissions for coronary heart disease. There was a statistically significant inverse association of serum sodium with all-cause mortality （P〈0.001）. After full adjustment comparing the highest serum sodium quartile to the lowest, there was a non-significant inverse association with all-cause mortality, with an adjusted hazard ratio （95% CI） of 0.67 （0.25-1.80）. After adjustment for age and increasing quartiles of serum sodium concentration were sex, the hazard ratio and 95% CI for final end-point events across 1.00,Aim： The aim of this study was to test the hypothesis that lower serum sodium may be associated with increased cardiovascular events and all-cause mortality by means of long-term follow-up of subjects with coronary atherosclerosis in a prospective, hospital-based epidemiological study in China. Methods： A prospective, hospital-based epidemiological design was used. The study population consisted of 1069 consecutive patients who were scheduled to undergo coronary angiography for suspected or known coronary atherosclerosis. The severity of coronary atherosclerosis was defined using Gensini＇s score system. Age, sex-adjusted hazard ratios （HR） and 95% confidence intervals （CI） for the quartiles of serum sodium concentration were estimated with Cox proportional hazard models, using quartile 1 as the reference. Cox proportional hazard models were also constructed to estimate the hazard ratios and 95% confidence intervals for all-cause mortality and final end-point events by serum sodium quartile and to adjust for potentially confounding variables. Multivariate models were adjusted for the following variables： age, sex, smoking status, alcohol consumption, body mass index, blood pressure, potassium, chloride, total cholesterol, triglycerides, fasting blood glucose, urea, creatinine, uric acid, and Gensini＇s score. Results： During the median 2.86 years （3011.66 person-years） of follow-up, 176 final end-point events were documented. These events included 79 deaths and 97 readmissions for coronary heart disease. There was a statistically significant inverse association of serum sodium with all-cause mortality （P〈0.001）. After full adjustment comparing the highest serum sodium quartile to the lowest, there was a non-significant inverse association with all-cause mortality, with an adjusted hazard ratio （95% CI） of 0.67 （0.25-1.80）. After adjustment for age and increasing quartiles of serum sodium concentration were sex, the hazard ratio and 95% CI for final end-point events across 1.00,

关 键 词：SODIUM coronary atherosclerosis FOLLOW-UP 

分 类 号：R541.4[医药卫生—心血管疾病] R720.597[医药卫生—内科学]