慢性溃疡创面床准备的疗效  

Efficacy of wound bed preparation on chronic ulcer wound

作　　者：谢春玲[1] 陈东[2] 朱家源[2] 朱斌[2] 唐冰[2] 蔡浩[2] 张伟[2] 

机构地区：[1]中山大学附属第一医院胸外科,广州510080 [2]中山大学附属第一医院烧伤科,广州510080

出　　处：《中华生物医学工程杂志》2008年第5期323-326,共4页Chinese Journal of Biomedical Engineering

摘　　要：目的观察创面床准备对慢性溃疡创面的疗效。方法2000年9月至2005年4月本院本科室的107例慢性溃疡创面人选患者，随机分为试验组（n=58）和对照组（n=49）。前者采用创面床准备方法进行创面处理，对照组采用传统创面处理方法，比较两组患者的住院天数、组织病理变化、创面情况变化及手术失败率。结果试验组的住院天数（35．1±26．8）d较对照组（49．7±32．9）d短（P〈0．05）。HE染色发现试验组创面组织变化朝有利于愈合的方向发展。试验组和对照组的换药后自愈率分别为26％（15／58）和10％（5／49）（P〈0．05）；植皮术手术失败率分别为9％（3／33）和23％（6／26）（P〉0．05）；皮瓣转移术失败率分别为0％（1／10）和44％（8／18）（P〈0．05）。结论创面床准备方法是慢性溃疡一种有效和科学的创面处理手段，可促进较小创面愈合。经创面床准备后选择手术覆盖创面可减少手术失败率，加快创面愈合。Objective To investigate the efficacy of wound bed preparation （WBP） on the chronic ulcer wound. Methods One hundred and seven patients with chronic ulcer wound admitted to our hospital from Sep 2000 to April 2005 were randomized into two groups. The trial group （ n = 58 ） received WBP as wound management therapy, while the control group（ n = 49） received traditional wound management therapy. Hospitalization days, pathological changes, wound changes and operation failure rate were compared between two groups. Results The hospitalization days in trial group were （ 35. 1 ± 26.8 ） d, shorter than that in control group （49.7 ± 32.9 ） d （ P 〈 0.05 ）. HE stain revealed WBP attributed wound changes to wound healing process in trial group . The self-healing rates in trial group and control group were 26% （15/58） and 10% （5/49） （P 〈 0.05 ）. The failure rate of skin graft operation was 9% （3/33）in trial group and 23% （6/ 26 ） in the control group （ P 〉 0.05 ）. The failure rate of transposition of skin flap was 0% （ 0/10 ） in trial group and 44% （8/18） in control group （ P 〈 0.05 ）. Conclusions WBP is an effective and scientific wound management therapy and can promote small wound self-healing. WBP management can reduce the failure rate of skin covering operation and accelerate the healing process.

关 键 词：皮肤溃疡 伤口愈合 创面 创面床准备 植皮术 皮瓣转移术 

分 类 号：R473.6[医药卫生—护理学]