细菌耐药性与抗菌药物的合理应用  

Drug Resistance and Rational Application of Antibiotics

作　　者：汪能平[1] 

机构地区：[1]南方医科大学南方医院医院感染管理科,广东广州510515

出　　处：《医学与哲学（B）》2009年第3期5-7,共3页Medicine & Philosophy(B)

摘　　要：面对细菌耐药性的客观存在,分別从四个方面讨论抗菌药物的合理应用,即首先是人类如何对待细菌、真菌等微生物,第二是人类如何对待抗菌药物,第三是人类如何认识细菌耐药性,第四是临床医师如何合理应用抗菌药物以确保最佳疗效及遏制细菌耐药性。笔者提出"六化",即做到用药适应证规范化,做到感染性疾病病原学诊断常规化,提倡感染性疾病病原学治疗选药合理化,逐步做到推广病原菌耐药性信息监测与反馈制度化,强调抗感染治疗用药方案个体化,评价疗效制度日常化。它是追求抗感染疗效最佳化,遏制病原菌耐药性有效化,力争抗菌药物不良反应最小化的基本措施。To face the objective existence of drug resistance of bacteria, rational application of antibiotics were discussed from four aspects. Firstly, how to deal with microbes？ Secondly, how to treat antibiotics？ Thirdly, how to understand the concept of drug resistance of bacteria？ Lastly, how to use the antibiotics rationally to get the effective therapy？ In this paper, six measures were suggested to meet above-mentioned points, namely, standardization of indications, routinization of pathogenetic diagnosis in infectious diseases, rationalization of drug selection in infectious diseases, institutionalization of surveillances and feedback of resistance information, individualization of medication in anti-infection treatment, and daily assessment of therapeutic value. Only that these measures were taken, could anti-infection be optimized and drug resistance be held back, so that adverse drug reaction could be minimized.

关 键 词：细菌耐药性 抗菌药物 合理用药 

分 类 号：R969.3[医药卫生—药理学]