七氟醚在新生儿全身麻醉中的应用  

Application of sevoflurane inhalaton anesthesia in newborn

作　　者：郝唯[1] 张建敏[1] 

机构地区：[1]首都医科大学附属北京儿童医院麻醉科,100045

出　　处：《临床麻醉学杂志》2009年第3期235-236,共2页Journal of Clinical Anesthesiology

摘　　要：目的研究七氟醚在新生儿全麻中的应用。方法60例年龄1～27d新生儿患儿随机均分为两组接受气管插管全麻:Ⅰ组使用8%七氟醚诱导、4%浓度维持;Ⅱ组采用8%七氟醚、芬太尼3μg/kg、罗库溴铵0.5mg/kg诱导,3%七氟醚维持。监测术前、切皮时、手术开始后15、30、60min及缝皮时的心率、血压。记录诱导至插管时间、停药至自主呼吸恢复时间和术毕至拔管时间。结果Ⅰ组诱导至插管时间长于Ⅱ组(P<0.05),停药至自主呼吸恢复时间以及术毕至拔管时间明显短于Ⅱ组(P<0.01)。与术前相比,Ⅱ组切皮时、手术开始后15min的心率减慢、血压降低(P<0.05);与Ⅱ组比较,Ⅰ组切皮时、手术开始15min的心率明显增快、血压明显升高(P<0.05)。结论七氟醚全凭吸入麻醉较七氟醚静吸复合麻醉安全性高。Objective To study the application of sevoflurane inhalaton anesthesia in newborn. Methods Sixty newborns aged 1 to 27 days were randomly divided two groups of general anaesthesia with sevoflurane inhalation alone（group A, 8 % sevoflurane for induction and 4 % for maintenance） and with sevoflurane combined with fentainl （group B,8% sevoflurane plus fentainl 3μg/kg for induction and 3% sevoflurane for maintenance）. The HR, BP were measured and the time from induction to intubation（T1）, the time from stopping inhalation to respiratory recovery （T2） and the time of extubation were recorded. Results T1 was longer but T2 was shorter in group A than those in group B. The HR and BP were lower in group A than those before anesthesia and in group B at 15 min after skin incision. Conclusion Sevoflurane inhalation alone is better than sevoflurane combined with fentainl for general anaesthesia in newborn with more safety.

关 键 词：七氟醚 新生儿 全身麻醉 

分 类 号：R726.1[医药卫生—儿科]