急性肝损伤动物模型的建立  

Establishment of the Animal Models of Acute Hepatic Injury

作　　者：田洪[1] 潘善庆[1] 陈子渊[1] 

机构地区：[1]湖南省药品检验所,长沙410001

出　　处：《中国药师》2009年第4期449-450,共2页China Pharmacist

摘　　要：目的:以对乙酰氨基酚、四氯化碳、氨基半乳糖为肝毒剂,建立急性肝损伤动物模型。方法:分别测定不同剂量对乙酰氨基酚、四氯化碳、氨基半乳糖所致急性肝损伤模型小鼠血清丙氨酸氨基转移酶(ALT)水平。结果:剂量为100 mg·kg^(-1)的对乙酰氨基酚、浓度为0.05%～1.0%四氯化碳及剂量600,800 mg·kg^(-1)的氨基半乳糖造模后均能明显升高小鼠血清ALT水平。结论:对乙酰氨基酚、四氯化碳、氨基半乳糖造模可用于保肝药的筛选与评价。Objective： To extablish the animal models of acute hepatic injury induced by acetaminophen, arbon tetrachloride and D-galactosamine. Method： The serum ALT level in those mice were determined. Result： The ALT level was significantly increased by ip acetaminophen 100mg· kg^- 1, ig 0.05 % - 1.0% carbon tetrachloride and ip D-galactosamine 600,800mg· kg ^- 1 respectively. Conclusion： The models made by these three drugs can be used for screening and evaluation of new drugs.

关 键 词：急性肝损伤 动物模型 对乙酰氨基酚 四氯化碳 氨基半乳糖 

分 类 号：R965.1[医药卫生—药理学]