铜绿假单胞菌耐药率与抗菌药使用量相关性分析  

Correlation Between Amount of Consumption of Antibacterials and Drug Resistance of Pseudomonas Aeruginosa

作　　者：郑晓林[1] 廖致红[1] 

机构地区：[1]广西医科大学第五附属医院,广西柳州545001

出　　处：《中国药师》2009年第4期457-459,共3页China Pharmacist

摘　　要：目的:探讨铜绿假单胞菌耐药率与9种常用抗菌药使用量的相关性。方法:采用回顾性调查方法,分别统计我院2003～2007年铜绿假单胞菌的耐药率及9种常用抗菌药的用药频度(DDDs),用直线回归方法对耐药率与用药频度进行相关性分析。结果:5年来铜绿假单胞菌对9种抗菌药的耐药率全部呈现增长态势,环丙沙星的耐药率最高。耐药率与用药频度的相关性显示,铜绿假单胞菌对环丙沙星、头孢他啶的耐药率与哌拉西林的用量呈显著负相关。结论:铜绿假单胞菌耐药率的上升趋势与抗菌药的大量使用有一定关系,临床应根据细菌耐药性合理选择抗菌药,以减少耐药菌株的产生。Objective： To analyse the correlation between the resistance of Pseudomonas aeruginosa and the DDDs of 9 antibacterials. Method： The resistance of Pseudomonas aeruginosa, and DDDs of 9 antibaeterials were analysed respectively from 2003 to 2007 in our hospital. The relationship between resistance rate and DDDs was analysed by using method of linear regression. Result： The resistance rates of Pseudomonas aeruginosa to 9 antibacterials were all increased in the last 5 years, the resistance rate of Ciprofloxaein was highest, and the analysis revealed DDDs of Piperacillin was significant inactive correlation with resistance of Ciprofloxaein and Cefmetazole. Conclusion： The increase of the resistance rate of Pseudomonas aeruginosa is somewhat related with the amounts of antibacterials usage, antibacterials should be regularly used in clinic according to the bacterial resistance, in order to reduce the resistant bacterial strains.

关 键 词：铜绿假单胞菌 耐药率 抗菌药 

分 类 号：R915[医药卫生—微生物与生化药学]