门脉高压大鼠胃粘膜屏障功能的实验研究  

EXPERIMENTAL STUDY ON THE BARRIER CAPABILITY OF GASTRIC MUCOSA IN PORTAL HYPERTENSIVE RATS

作　　者：周东风[1,2] 孙作祥[1,2] 梁桂华 李红梅[1,2] 王占民 

机构地区：[1]山东省济宁医学院附属医院肝胆外科 [2]山东医科大学附属医院普外科

出　　处：《中国普外基础与临床杂志》1998年第3期135-137,共3页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：为探讨门脉高压性胃病的发病机理，将Ｗｉｓｔａｒ大鼠４２只随机分为肝硬变组（ＬＣ组，ｎ＝１５）、门静脉狭窄组（ＰＶＳ组，ｎ＝１５）和假手术组（ＳＯ组，ｎ＝１２），以观察其血流动力学指标、胃壁结合粘液（ＧＰ）、胃粘膜内源性前列腺素Ｅ２（ＰＧＥ２）水平、胃基础泌酸量（ＢＡＳ）以及Ｈ＋返渗量（Ｈ＋ＢＤ）。结果：ＬＣ组及ＰＶＳ组大鼠内脏血流量较ＳＯ组明显增加（Ｐ＜０．００１），但胃粘膜却处于缺血状态；其ＧＰ和ＰＧＥ２含量也较ＳＯ组显著下降（Ｐ＜０．０１），其中ＬＣ组又较ＰＶＳ组更低（Ｐ＜０．０５）；ＢＡＳ３组间无差异，但ＬＣ组及ＰＶＳ组大鼠之Ｈ＋ＢＤ明显高于ＳＯ组（Ｐ＜０．００１），且以ＬＣ组最为显著。本实验结果提示：门静脉高压大鼠胃粘膜屏障功能遭到严重破坏，尤以肝硬变大鼠为甚；门脉高压性胃病的发生与胃粘膜屏障功能削弱有关；肝功能受损参与胃粘膜病变的发生。Wistar rats were divided into three groups at random, liver cirrhosis (LC), portal vein stricture (PVS) and sham operation (SO) group. The changes of barrier capability of gastric mucosa in portal hypertensive rats were observed. The results demonstrated: the splanchnic blood flow of the portal hypertensive rats increased, as compared with the normal control group ( P <0.001), but actually gastric mucosa was under the condition of ischemia. Mucosa of gastric wall glycoprotein and PGE 2 of gastric mucosa decreased, as compared with the normal control ( P <0.01); and more seriously decreased in cirrhotic portal hypertensive rats, there was no significant difference about amount of the basal acid secretion (BAS) among the three groups, but the amount of H + back diffusion (H +BD) was obviously increased, as compared with the normal control group ( P <0.001). The amount of H +BD of cirrhotic portal hypertensive rats was the highest among this three groups. The results suggest that the barrier capability of gastric mucosa with portal hypertension is lower than that of the normal control group and much lower with cirrhotic portal hypertensive rats. The portal hypertensive gastropathy is associated with the lower capability of defense of gastric mucosa. The condition of liver function contributes to the change of barrier capability of gastric mucosa.

关 键 词：门静脉高压 胃粘膜屏障功能 肝硬变 

分 类 号：R657.34[医药卫生—外科学]