正常人的肺泡毛细血管膜弥散能力和肺毛细血管床容量  

Alveolar capillary membane diffusing capacity and pulmonary capillary blood volume in normal adults

作　　者：刘又宁[1] 茌璐琪[1] 朴哲龙[1] 郝峰英[1] 张青勉 

机构地区：[1]解放军总医院呼吸科

出　　处：《军医进修学院学报》1998年第2期132-134,共3页Academic Journal of Pla Postgraduate Medical School

摘　　要：目的：测定正常成人的肺弥散能力（ＤＬ）、肺泡毛细血管膜弥散能力（Ｄｍ）及肺毛细血管床容量（Ｖｃ），计算与年龄、身高、体重相关的回归方程；研究年龄对于ＤＬ特别是对Ｄｍ、Ｖｃ的影响以及后三者之间的关系。方法：单次呼吸法测定ＤＬＣＯ，测定不同吸入气氧分压下的ＤＬＣＯ，采用Ｒｏｕｇｈｔｏｎ和Ｆｏｓｔｅｒ方法计算Ｄｍ和Ｖｃ。结果：年龄与ＤＬ、Ｄｍ、Ｖｃ呈中度或高度负相关，ＤＬ与Ｄｍ和Ｖｃ、ＶＡ与ＤＬ、Ｄｍ和Ｖｃ中度或高度正相关；ＤＬ、Ｄｍ在４０岁以后开始降低，Ｖｃ在５０岁以后开始降低；在各年龄组ＤＬ、Ｄｍ和Ｖｃ的回归方程中，身高和／或年龄为进入公式的主要变量。结论：（１）年龄与Ｄｍ、Ｖｃ呈线性负相关；（２）Ｄｍ在４０岁以后开始降低，Ｖｃ减少发生在５０岁以后；（３）ＤＬ在４０岁以后随年龄增加而减少主要是由于Ｄｍ、Ｖｃ的降低所引起；（４）Ｄｍ、Ｖｃ的减少与ＶＡ随年龄变化有关；（５）身高和／或年龄是Ｄｍ。Objective: Measuring pulmonary diffusing capacity (DL), alveolar capillary membrane diffusing capacity (Dm) and pulmonary capillary blood volume (Vc) in normal adults; calculating the regression equation correlated to age, height and body weight; evaluating the effect of age on Dm and Vc; studying the relationship among DL, Dm and Vc.Methods:Spirometry was performed in the sit position. Several measurements of diffusint capacity of the lung for carbon monoxide (DL CO) were taken by singlebreath method at increasing alveolar oxygen tension (PA O2). The estimations of Dm and Vc were done by the method of Roughton and Forster.Results:(1)There was a significant negative corelation between age and DLCO, Dm and Vc. The correlations between DL and Dm, Vc as well as VA and DL, Dm, Vc are significantly positive.(2)DL and Dm decreased after 40 and Vc decreased after 50. DL/VA Dm/VA and Vc/VA decrease after 60 years of age. There was no significant difference of Dm/Vc among groups. (3)Height and/or age were the main variables in stepwise multiple linear regression equations for DL, Dm AND Vc in all groups.Conclusion:(1)There is a significant negative correlation between age and DL, Dm and Vc.(2)DL and Dm decrease after 40 and Vc decrease after 50. Age has not a significant influnce on Dm/Vc.(3)The declining in DL may be due to the decrease of Dm and Vc. (4)The decrease of Dm may be related to the reduction of VA with age. (5)Height and/or age are the main variables in regression equations for DL, Dm and Vc.

关 键 词：血气屏障 肺毛细血管床 容量 肺泡 DM VC 

分 类 号：R332.2[医药卫生—人体生理学]