蛇毒抗栓酶Ⅲ号对肺心病急性发作期疗效分析  

Therapeutic Effect of Snake venom antithrombotic enzyme-3 to Treat Patients with Pulmonary Heart Disease in Acute attack

作　　者：周菊芝 潘伟民[2] 

机构地区：[1]浙江省宁波卫生学校内科教研组,宁波315010 [2]宁波市第一医院

出　　处：《浙江中西医结合杂志》1998年第3期129-131,共3页Zhejiang Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的：评价蛇毒抗栓酶Ⅲ号对肺心病急性发作期疗效。方法：采取对肺心病急性发作期使用蛇毒抗栓酶Ⅲ号和常规疗法（蛇毒组）治疗，并与单纯常规疗法（对照组）作对照。结果：蛇毒组的部分缓解所需天数明显少于对照组（P＜0.01），组织型纤溶酶原激活物（tpA）含量明显高于对照组（P＜0.01），血浆丙二醛水平明显低于对照组（P＜0.05），血液流变学和血气分析的多项指标改善也优于对照组。结论：蛇毒抗栓酶可能通过提高tpA含量纠正高凝状态和纤溶功能低下，使治疗更能发挥作用。篢o evaluate the effect of svate-3 to treat pulmonary heart diseas in acute attack. Metkeds：The patients with pulmonary heart diseasein acute attack stage were treated by snake vonomantithrombotic enzyme-3 (svate-3) combining routine therapy（Snake venom group），Contrasting with patients treated with routine therapy alone.（controlled group）.Results：Snake venom group needs less day to partly relive than controlled group （P＜0.01），content of tissue-plasminogen activator（TPA）was obviously higher than controlled group（P＜0.01）.The concentration of the plasma MDA was obviously lower than of the controlled group （P＜0.05）. Many indexs of blood rheology and blood-gas analysis were improved much more than that of the controlled group.Conclusion：It showed that svate-3 could correct hypercoagulability and improve hypofunction of fibrinolysis by raising the content of TPA so as to improve the therapeutic effect.

关 键 词：蛇毒抗栓酶 肺心病 过氧化脂质 药物疗法 

分 类 号：R541.505[医药卫生—心血管疾病] R977.2[医药卫生—内科学]