染发皮炎的发病机制研究进展  

Advances in mechanism of hair dye dermatitis

作　　者：徐宏俊[1] 刘全忠[1] 

机构地区：[1]天津医科大学总医院皮肤性病科,300052

出　　处：《国际皮肤性病学杂志》2009年第2期98-100,共3页International Journal of Dermatology and Venereology

摘　　要：对苯二胺是染发剂的主要功能成分，也是染发皮炎的主要致敏物质之一。研究表明，树突细胞的激活、某些细胞因子及γδT细胞等可能参与对苯二胺引起的变态反应。人类乙酰转移酶、血管紧张素转换酶、锰超氧化物歧化酶等的基因多态性也可能与染发皮炎的发生有关。对染发皮炎可能涉及的免疫因素、遗传易感性的研究进展进行概述。Para-phenylenediamine is the main functional component of hair dyes, and also a most potent contact allergen in hair dye dermatitis. Studies have shown that the activation of human dendritic cells, production of some cytokines, and γδT cells are involved in p-phenylenediamine allergy. The genetic polymorphism of N-acetyltransferase, angiotensin-converting enzyme and manganese superoxide dismutase is reported to be associated with the development of hair dye dermatitis. This article gives an update on hair dye dermatitis-related immune factors and genetic susceptibilities.

关 键 词：皮炎 接触性 染发剂 免疫 

分 类 号：R758.22[医药卫生—皮肤病学与性病学]