醛糖还原酶及其遗传多态性与糖尿病慢性并发症的相关性  

Association of aldose reductase and its genetic polymorphisms with diabetic chronic complications

作　　者：程欢莲[1] 欧阳冬生[1] 

机构地区：[1]中南大学临床药理研究所

出　　处：《中国临床药理学与治疗学》2009年第2期225-229,共5页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：糖尿病慢性并发症(DCC)严重危害人类健康,是糖尿病致残、致死的主要原因。醛糖还原酶——多元醇代谢通路的限速酶,参与DCC的发生发展。编码醛糖还原酶的基因具有多态性和种族差异,其多态性与DCC的易感性有关,了解两者的关系有助于并发症的防治。Diabetic chronic complications （DCC） are severely harmful to the health of human, and are major causes leading to death and deformity from diabetes. Aldose reductase （AR）, a rate limiting enzyme in polyol metabolic pathway, has implicated in the pathogenesis and development of DCC. The polymorphisms in AR gene are proved to be ethnic different. These polymorphisms are related to DCC susceptibility. The investigation on the polymorphisms may be helpful to prevention and therapy of DCC.

关 键 词：醛糖还原酶 糖尿病慢性并发症 多态性 

分 类 号：R587.1[医药卫生—内分泌]