脑蛋白水解物与单唾液酸四已糖神经节苷脂联合治疗新生儿缺血缺氧性脑病65例  

作　　者：邓郁芬[1] 杨彩平[1] 

机构地区：[1]广东东莞市虎门医院儿科,523900

出　　处：《中国社区医师（医学专业）》2009年第3期54-54,共1页

摘　　要：目的:探讨单用脑蛋白水解物与联合使用单唾液酸四已糖神经节苷脂,治疗新生儿缺血缺氧性脑病的临床疗效。方法:随机分成两组。治疗组(联合使用脑蛋白水解物与单唾液酸四已糖神经节苷脂n=35);对照组(脑蛋白水解物治疗组n=30)。两组病人均在对症支持处理的基础上进行,观察比较两组患儿神经系统症状体征的恢复时间,HIE 临床,NBNA评分。结果:治疗组新生儿症状体征恢复时间明显较对照组缩短,P<0.01,差异有显著性,生后7～8天,10～14天NBNA评分治疗组分值高于对照组,P<0.05,差异有显著意义。结论:联合使用脑蛋白水解物与单唾液酸四已糖神经节苷脂治疗HIE,较单用脑蛋白水解物能显著缓解症状体征,缩短病程,减轻脑损伤,提高治愈率。Objective：To investigate the curattive effect of GM - I combined with cerebroprotein hydrolysate on hypoxic - ischemie encephalopathy （HIE） in neonate . Methods：65 cases of neonatal hypoxlc - ischemic encephalopathy were divided randomly into observation group （ n = 35 ） and control group（n =30）. In addition to individualized supportive treatment, patients in control group were treated with cerebroprotein hydrolysate, patients in observation group were treated with ganglioside GM - I combined with cerebroprotein hydrolysate. The duration of recovery and the changes of neonatal behavior neurological assessment （ NBNA ） in the two groups were compared. Results： The recovery time of observation group was obviously shorter than that of control group with a singnificant difference （ P 〈 0. 01 ） ; Meanwhile postnatal NBNA at 7and at 14 in observation group were obviously higher than those of control group with a singnificant difference （ P 〈 0. 05 ）. Conclusion ： Combi- nation Ganglioside GM - Ⅰ with cerebrpro- tein hydyolysate therapy can improve clinic curative effect, lower duration of recovery, and reduce incidence of disability in neonates with HIE.

关 键 词：新生儿缺血缺氧性脑病 脑蛋白水解物 单唾液酸四已糖神经节苷脂 

分 类 号：R722.12[医药卫生—儿科] R977.6[医药卫生—临床医学]