小檗胺衍生物(EBB)体内抗肿瘤作用初探  

Effect of Berbamine Derivative(EBB)on Anticancer and Immune Function of Tumor-bearing Mice

作　　者：张金红[1] 毛启龙[1] 许乃寒[1] 陈家童[1] 

机构地区：[1]南开大学分子生物学研究所,天津300071

出　　处：《中草药》1998年第4期243-246,共4页Chinese Traditional and Herbal Drugs

基　　金：天津市自然科学基金

摘　　要：以荷S180瘤小鼠为模型，初步探讨了EBB抗肿瘤的作用及其特点。实验结果发现，EBB具有明显的抗体内移植瘤作用，其特点是单独使用EBB具有与抗肿瘤药环磷酰胺和丝裂霉素相同水平的抑制效果和延长存活期的作用；而EBB分别与这两种药联合使用时，能使抑瘤能力有所增强并能提高生存质量。此外，EBB无论是单独使用还是与抗癌药联合使用，都能逆转由于荷瘤造成的胸腺指数下降的现象；EBB与抗癌药联合使用也能使肿指数恢复基本正常；说明EBB在抑制体内肿瘤生长的同时，还能提高机体的免疫能力。提示EBB是一种有前途的抗肿瘤化合物。EBB is a berbamine derivative developed in our laboratory by structural modification of berbamine and has been demonstrated as a new and strong calmodhlin antagonist.Previous studies showed that EBB can strongly inhibit the proliferation of tumor cells.Effect of EBB on the anticancer and immune function of S180-bearing mice was presented in the present paper.Experimental results showed that the effect of EBB on inhibition of tumor and prolongation of life-span were comparable to mitomycin-C (Mit-C)or cy clophsphamide (CPA).It also showed that a combined used of both EBB/Mit-C or EBB/CPA gave a better therapeutic result than Mit-C or CPA alone.It was also found that EBB can improve immune function of S180 bearing mice,with significant increase of the index of thymus. There fore,EBB can be considered as a potent anticancer compound.

关 键 词：小檗胺衍生物 抗肿瘤作用 胸腺指数 脾指数 

分 类 号：R979.1[医药卫生—药品] R978[医药卫生—药学]