不同方式给铝对大鼠体内金属硫蛋白诱导作用的初步研究  

A Preliminary Study on the Induction of Metallothioneine in Rats with Aluminum Administration by Different Ways

作　　者：张万起[1,2,3] 帖建科 沈海铭 徐格晟[1,2,3] 茹炳根[1,2,3] 

机构地区：[1]天津医科大学营养与食品卫生教研室 [2]北京大学生命科学中心 [3]浙江省绍兴文理学院

出　　处：《中华预防医学杂志》1998年第3期153-155,共3页Chinese Journal of Preventive Medicine

摘　　要：目的研究体内铝与金属硫蛋白的关系。方法１６只ＳＤ大鼠按实验和对照两种剂量水平，通过皮下注射和灌胃两种给铝方式进行为期两周的铝对金属硫蛋白（ＭＴ）诱导实验。结果铝对大鼠肝ＭＴ具有一定的诱导作用，其中以皮下注射方式给铝较经口方式的作用显著。经口给铝对小肠也存在一定诱导作用。结论铝对ＭＴ的诱导体现了机体对铝这一金属毒物的应激反应，但由于铝的化学性质，推测其与ＭＴ结合不稳定，因此这一反应实际解毒作用尚不确定。此外铝对小肠和肝等不同部位ＭＴ的诱导。Objective To study the inductive effects of aluminum (Al) on metallothioneine (MT) in rats. Methods Inductive experiment of MT was conducted with Al administration in 16 SD rats, divided into trial and control groups, for two weeks by subcutaneous injection and gastric tube. Results Al could induce liver MT in the rats, to certain extent, especially more significantly by subcutaneous injection than by oral administration of Al. Oral administration of Al also could induce MT in the small intestine. Induction of MT by Al reflected the body response to stress, the metal poison Al. Conclusion It postulated that combination of Al with MT was unstable due to its chemical property, so, its detoxication effect was uncertain. In addition, induction of MT in different sites, such as liver and small intestine, by Al could influence the normal metabolism of metal elements, such as zinc, etc.

关 键 词：铝 金属硫蛋白 诱导作用 毒性 

分 类 号：R995[医药卫生—毒理学]