氯化钇和氯化镨对人血淋巴细胞微核率的影响  

Studies on Effects of Yttrium Chloride and Praseodymium Chloride on Frequency of Micronucleus in Human Blood Lymphocytes

作　　者：杨辉[1] 嵇庆[1] 张锡然[1] 

机构地区：[1]南京师范大学生物系

出　　处：《中华预防医学杂志》1998年第3期156-158,共3页Chinese Journal of Preventive Medicine

摘　　要：目的探讨稀土元素钇和镨的遗传毒性。方法用微核试验法研究了氯化钇和氯化镨对体外培养的人淋巴细胞微核率的影响。结果钇和镨能够引起人血淋巴细胞微核率显著升高，在一定范围内，微核率随氯化钇、氯化镨处理浓度的增大而提高。Objective To explore genotoxicity of rare earth elements, yttrium and praseodymium. Methods Effects of yttrium chloride and praseodymium chloride on human lymphocytes cultured in vitro were studied by micronucleus test. Results Frequency of micronucleus in human blood lymphocytes increased significantly by treatment with yttrium chloride and praseodymium chloride, and it increased with the concentration of the both agents, to a certain range. Conclusion It suggests that rare earth elements yttrium and praseodymium have certain genotoxicity.

关 键 词：氯化钇 氯化镨 淋巴细胞 微核试验 遗传毒性 

分 类 号：R995[医药卫生—毒理学]