高原红细胞增多症的左心功能改变  

CHANGES OF LEFT HEART FUNCTION IN PATIENTS WITH HIGH ALTITUDE POLYCYTHEMIA

作　　者：王小珍[1] 吴天一[1] 陈秋红[1] 魏春英 

机构地区：[1]青海省高原医学科学研究所

出　　处：《解放军预防医学杂志》1998年第2期97-99,共3页Journal of Preventive Medicine of Chinese People's Liberation Army

摘　　要：为观察高原红细胞增多症（ＨＡＰＣ）的左心功能改变情况，应用心阻抗图和心机械图对２１例高原红细胞增多症患者进行了心泵功能和左室收缩功能的测定，并以２４名高原健康人（ＨＡＨＲ）作对照，结果显示患者的心搏指数（ＳＩ）、心指数（ＣＩ）下降，ＨＡＰＣ及ＨＡＨＲ的ＳＩ分别为３１．６６±８．０６及４１．８６±１０．２６ｍｌ·ｍ－２，ＣＩ分别为２．６８±０．６７及３．４１±０．８０Ｌ·ｍｉｎ－１·ｍ－２，均Ｐ＜０．０５。ＨＡＰＣ的射血前期（ＰＥＰ）及等容收缩期（ＩＣＴ）延长，ＰＥＰ分别为１１２．００±９．４２及１０２．００±１４．４２，Ｐ＜０．０５，ＩＣＴ分别为４２．５２±１２．１０及３１．８３±１３．４０，Ｐ＜０．０１，ＰＥＰ与左室射血时间比值（ＰＥＰ／ＬＶＥＴ）增大（分别为０．４０±０．０５及０．３５±０．０４，Ｐ＜０．０１）。提示，高原红细胞增多症患者的心功能减退，认为与其心肌缺氧和后负荷过重有关。In order to study the changes of cardiac function in patients with high altitude polycythemia (HAPC), 21 cases HAPC and 24 healthy residents at high altitude( HAHR) were studied by electrical impedance and mechanocardiograph. The results showed that in HAPC, stroke index(SI) and cardiac index (CI) both were decreased, for SI 31.66±8.06 vs 41.86±10.26 ml·m -2 that of HAHR, and for CI 2.68±0.67 vs 3.41±0.80 L·min -1 ·m -2 ,P<0.05 both. Preejection period (PEP) and isovolemic contraction time (ICT) lengthened in HAPC than HAHR ,(112.00±9.42 vs 102.00±14.42 ms for PEP, and 42.52±12.10 vs 31.88±18.40 ms for ICT, P<0.05 and P<0.01 respetively), and the ratio of PEP and left ventricle ejection time, i.e. PEP /LVET ,increaset (0.40±0.05 vs 0.35± 0.04,P<0.01).These results proved that carcliac function in HAPC was decreased, and it may be caused by myocardial hypoxia and increased afterload.

关 键 词：缺氧 红细胞增多 心功能 高原病 

分 类 号：R555.1[医药卫生—血液循环系统疾病] R594.3[医药卫生—内科学]