MC9204对大鼠心肌肥厚模型的影响  

Effects of MC9204 on cardiac hypertrophy model in rats

作　　者：李姁君[1] 梅其炳[1] 赵德化[1] 崔毅[1] 

机构地区：[1]第四军医大学基础部药理学教研室,西安710033

出　　处：《第四军医大学学报》1998年第2期164-166,共3页Journal of the Fourth Military Medical University

基　　金：国家自然科学基金资助项目 NO.39400053

摘　　要：目的:观察新的二氢吡啶类钙拮抗剂MC9204对大鼠心肌肥厚的影响.方法:建立大鼠腹主动脉狭窄左室肥厚(LVH)模型,并给予新的二氢吡啶类钙拮抗剂MC9204治疗3mo,观察大鼠LVH时心肌重量指数、心室厚度、氧自由基(OFR)、心肌酶释放等的变化.结果:LVH时全心重量指数(HW/BW)、左室重量指数(LVW/BW)和左心室、室间隔厚度均显著增高(P<0.01),表明LVH模型成立;LVH时丙二醛(MDA)明显增高,超氧化物歧化酶(SOD)显著下降(P<0.01);并伴有肌酸激酶(CPK)和乳酸脱氢酶(LDH)升高(P<0.01).MC9204可逆转上述LVH时的各种改变(P<0.01).结论:OFR产生增多,清除减少,可能参与心肌肥厚的发展;MC9204具有逆转肥厚心肌的效应,该作用可能与其抑制钙内流、降低心脏负荷以及维持OFR产生-清除系统的平衡有关.To study effects of MC9204, a dihydropy-ridine calcium antagonist, on cardiac hypertrophy model in rats. Methods: Rat abdomino aorta was narrowed for 3 months to establish a left ventricular hypertrophy (LVH) model, and given by an administration of MC9204 to investigate its effects. Heart weight/body weight (HW/BW), left ventricular weight/body weight (LVW/BW) , left ventricular wall thickness (LVWT) , ventricular septal thickness (VST) and makmdialdehyde(MDA), superoxide dismutase (SOD), creatine kinase (CPK) and lactic dehydrogenase (LDH) were measured. Results: HW/BW, LVW/BW, LVWT, VST of LVHC(LVH control) were significantly higher than those ofoperation control (P<0. 01), which suggested LVH model was successful. MDA, LDH, CPK were statistically increased whereas SOD was decreased in LVHO(P<0. 01), The changes were improved by MC9204 administration(P< 0. 01). Conclusion: Oxygen free radical(OFR) is increased while clearance of it is decreased in LVH, indicating OFR may play a role in the development of LVH. MC9204 had beneficial effects on LVH, which may be related to its block of calcium entry, decrease of the cardiac burden and the keeping of the balance of OFR production and clearance system.

关 键 词：心肌肥厚 二氢吡啶 钙拮抗剂 氧自由基 

分 类 号：R972.4[医药卫生—药品] R542.205[医药卫生—药学]