缓释烟酸与阿托伐他汀联合治疗颈动脉粥样硬化的疗效观察  

The Effects of Extended-release Niacin Combined with Atrovastatin on the Therapyment of Carotid Atherosclerosis

作　　者：袁夏英 曹志凌 何玉兰 

机构地区：[1]湖南省汝城县人民医院,湖南汝城424100

出　　处：《中外医疗》2008年第32期16-18,共3页China & Foreign Medical Treatment

摘　　要：目的研究烟酸缓释片联合阿托伐他汀对颈动脉粥样硬化的治疗效果。方法76例颈动脉粥样硬化患者随机分为两组:(1)对照组(38例),给予阿托伐他汀10mg/d;(2)治疗组(38例),给予阿托伐他汀10mg/d和烟酸缓释片1000mg/d。比较治疗前后两组血清总胆固醇(TC)、血清甘油三酯(TG)、血清低密度脂蛋白(LDL-C)和高密度脂蛋白(HDL-C)水平的改变;颈总动脉内膜-中层厚度(IMT)、颈动脉斑块厚度(Tmax)、颈动脉斑块面积(Smax)变化。结果(1)经过6个月治疗,两组TC、TG、LDL-C均有明显下降(P<0.05),但治疗组较对照组下降更显著(P<0.001)。治疗组血清高密度脂蛋白(HDL-C)升高20.7%,对照组无明显变化。(2)治疗后,治疗组的IMT、Tmax、Smax较治疗前明显下降,而对照组较治疗前无明显变化(P>0.05)。结论烟酸缓释片联合阿托伐他汀治疗颈动脉粥样疗效较单独使用阿托伐他汀好,且具有良好的安全性和耐受性。Objective To investigate the effects of extended-release niacin （niacin ER） combined with atrovastatin on the regression of carotid atheroscleresis. Methods 76 patients with carotid atherosclerosis were randomly assigned into two groups：（1）contrast group （n=38）,given atrovastatin 10mg//d;（2）treat group（n=38）,treated with atrovastatin （10mg/d） plus niacin ER （1000mg/d）.The varieties of serums lipid （including TC,LDL-C,TG,HDL-C）, IMT, Tmax and Smax of two groups were compared. Results （1）After 6 months of treatment,the serum level of TC,LDL-C,TG were decreased significantly after administration in both groups （P〈0.05）, but there have significant difference between the two groups （P〈0.00I）. Combination treatment increased the level of HDL-C of patients in treat group by 20.7%,and no increase in contrast group.（2）IMT,Tmax and Smax,were decreased significantly after administration in treat group （P〈0.001）,however,there were no difference in contrast group （P〉0.05）. Conclusion niacin ER combined with atrevastatin is more effective than atrovastatin alone in the regression of carotid atheroscleresis,and is generally safe and well tolerable.

关 键 词：缓释烟酸 阿托伐他汀 动脉粥样硬化 

分 类 号：R543.5[医药卫生—心血管疾病]