四乙铵对正常及肺动脉高压大鼠肺动脉平滑肌细胞外向钾电流作用的比较  

Comparison of effect of tetraethylammonium on the outward potassium current of pulmonary artery smooth muscle cell of normal and pulmonary hypertensive rats1

作　　者：张庆利[1] 李智[1] 丛华[1] 李金鸣[1] 赫梅生[1] 

机构地区：[1]中国医科大学基础医学院药理学教研室

出　　处：《中国药理学与毒理学杂志》1998年第2期98-100,共3页Chinese Journal of Pharmacology and Toxicology

基　　金：中国卫生部八.五攻关资助

摘　　要：以全细胞膜片钳制技术观察了正常及慢性常压低氧肺动脉高压大鼠肺动脉平滑肌细胞外向钾电流，并进行了四乙铵（ＴＥＡ）对两种动脉外向钾电流作用的量效关系比较．结果表明：将细胞膜电位钳制在－５０ｍＶ，当指令电位大于－５０ｍＶ时，可以记录到电压依赖性的外向钾电流，且慢性常压低氧肺动脉高压时该电流较正常时为小；当指令电位为＋７０ｍＶ。The outward potassium currents (Ik) of normal and chronic normobaric hypoxic pulmonary hypertensive rats and the effect of tetraethylammonium(TEA) on them were observed. The results showed that when cell membrane potential was held at -50 mV and command potential was larger than -50 mV, the Ik of pulmonary hypertensive rats was smaller than that of normal rats. When command potential was +70 mV, the doseeffect curve of TEA on the Ik of pulmonary hypertensive rats was rightshifted compared to that of normal rats.

关 键 词：肺动脉高压 四乙铵 肺动脉 平滑肌细胞 

分 类 号：R543.2[医药卫生—心血管疾病] R331.32[医药卫生—内科学]