超氧阴离子对脑片谷氨酸释放的增强及依布硒的抑制  

Glutamate release increased by superoxide anion radical and the protection of ebselen

作　　者：易永[1,2] 杨祥良[1,2] 徐辉碧 赵西龙[1,2] 张亨山[1,2] 秦钰慧[1,2] 

机构地区：[1]华中理工大学化学系 [2]中国预防医学科学院环境卫生监测研究所毒理室

出　　处：《中国药理学与毒理学杂志》1998年第2期155-156,共2页Chinese Journal of Pharmacology and Toxicology

摘　　要：超氧阴离子对脑片谷氨酸释放的增强及依布硒的抑制易永杨祥良徐辉碧赵西龙１张亨山１秦钰慧１（华中理工大学化学系，武汉４３００７４；１中国预防医学科学院环境卫生监测研究所毒理室，北京１０００２１）兴奋性毒性是神经系统疾病中神经元损伤的一种重要病理机理，其特...DLGlutamate release increased by superoxide anion radical (O÷2) and the protection of ebselen were studied in rat cortical slices. Exposure of rat cortical slices to xanthine/xanthine oxidase, a O÷2 generating system, resulted in a marked increase in nondepolarized release of DLglutamate. Ebselen showed a blockade effect on the increase in glutamate release by O÷2.

关 键 词：超氧阴离子 大脑皮层 组织切片 谷氨酸 依布硒 

分 类 号：R977.9[医药卫生—药品] R363[医药卫生—药学]