肉桂对豚鼠哮喘模型血清中TXB_2及6-keto-PGF_(1α)的影响  

Effect of Rougui on TXB_2 and 6-keto-PGF_(1α) in Serum Of Guinea Pig with Asthma

作　　者：王振强 侯仙明[2] 李贺芝[2] 贾云芳[2] 张洪芝 刘吉伟[3] 

机构地区：[1]河北省泊头市眼耳鼻喉科医院,泊头062150 [2]河北医科大学中医学院,050091 [3]石家庄医学高等专科学校

出　　处：《河北中医药学报》2009年第1期3-4,共2页Journal of Hebei Traditional Chinese Medicine and Pharmacology

基　　金：河北省中医药管理局资助项目:No2007020

摘　　要：目的:观察豚鼠哮喘模型血清中TXB2及6-keto-PGF1α的变化,对肉桂平喘作用的机理进行初步探讨。方法:用不同浓度肉桂提取物作用于豚鼠哮喘模型,观察其对血清中TXB2和6-keto-PGF1α的影响。结果:肉桂使血清中的TXB2的水平降低,而6-Keto-PGF1α水平上调,并且TXB2/6-Keto-PGF1α的比值显著性下降。结论:肉桂的作用机制可能是通过缓解慢性炎症,进而缓解支气管平滑肌的痉挛达到平喘的作用。Objective:to observe TXB2 and 6-keto-PGF1α in serum of guinea pig models, and to explore the mechanism of Rougui relieving asthma. Methods: Rougui Extracts of different concentrations were given to guinea pig models to observe the effect on TXB2 and 6-keto-PGF1α in serum.Results: Rougui lowered TXB2 level, heightened 6-keto-PGF1α, and the ratio of TXB2 and 6-keto-PGF1α decreased significantly. Conclusion: Rougui relieving asthma may achieved by alleviating chronic inflammation and then easing the spasm of bronchial smooth muscle.

关 键 词：肉桂 支气管哮喘 TXB2 6-KETO-PGF1Α 

分 类 号：R285.5[医药卫生—中药学]