强效GnRH激动剂那法瑞林对兔异位子宫内膜的抑制作用  

Effect of a high potent gonadotropinreleasing hormone agonist nafarelin on experimentally induced endometriosis in rabbits

作　　者：李娟[1,2] 周美华[1,2] 高允生[1,2] 褚云鸿 

机构地区：[1]泰山医学院药理学教研室 [2]上海医科大学基础医学院药理学教研室

出　　处：《中国药理学通报》1998年第2期122-124,共3页Chinese Pharmacological Bulletin

摘　　要：目的研究强效促性腺激素释放激素（ｇｏｎａｄｏｔｒｏｐｉｎ－ｒｅｌｅａｓｉｎｇｈｏｒｍｏｎｅ，ＧｎＲＨ）激动剂那法瑞林（ｎａｆａｒｅｌｉｎ，Ｎａｆ）对兔异位子宫内膜的抑制作用。方法以手术方法制备兔异位子宫内膜模型后，将动物分为对照组、Ｎａｆ（１，３，１０μｇ·ｋｇ－１·ｄ－１各１组，ｓｃ）治疗组，丹那唑（ｄａｎａｚｏｌ，Ｄａｎ，８０ｍｇ·ｋｇ－１·ｄ－１，ｉｇ）治疗组以及手术切除双侧卵巢组（ｂｉｌａｔ－ｅｒａｌｏｖａｒｉｅｃｔｏｍｙ，ＯＶＸ）。结果６ｗｋ后发现，经Ｎａｆ治疗的动物其异位内膜的体积明显减小，其中３和１０μｇ·ｋｇ－１·ｄ－１剂量组的疗效与ＯＶＸ组相似。Ｄａｎ尽管也能引起异位内膜萎缩，但其疗效较Ｎａｆ１０μｇ·ｋｇ－１·ｄ－１和ＯＶＸ有显著差别。另外，Ｎａｆ治疗组动物的血清雌二醇（ｅｓｔｒａｄｉｏｌ，Ｅ２）水平也明显下降。结论Ｎａｆ可明显抑制兔异位子宫内膜的生长，该作用与兔血清内Ｅ２水平下降有关。AIM To study effect of a high potent gonadotropinreleasing hormone (GnRH) agonist nafarelin (Naf) on endometrial implants in rabbits. METHODS Endometriosis was surgically induced in New Zealand white rabbits in the first 4 wk. Then the animals were treated with Naf (1,3 or 10 μg·kg-1·d-1, sc), danazol (Dan 80 mg·kg-1·d-1, ig) or bilateral ovariectomy (OVX) for 6 wk. RESULTS In the last 6 wk, implants in control group continued to grow, while those in groups treated with Naf shrinked significantly, and the effects of Naf 3 and 10 μg·kg-1·d-1 were similar to that of OVX. Moreover, serum estradiol concentrations in those treated animals were also markedly reduced. CONCLUSION Chronic treatment with Naf results in atrophy of ectopic endometrial tissue, which is associated with its inducing a state of “medical oophorectomy”.

关 键 词：GNRH激动剂 那法瑞林 子宫内膜异位 药物疗法 

分 类 号：R977.1[医药卫生—药品] R711.710.5[医药卫生—药学]