金鸡纳碱衍生二胺催化丙酮和α-酮酸酯的Aldol反应  

Aldol Reactions of α-Keto Acid Esters and Acetone Catalyzed by Cinchona Alkaloid Derived Primary Amines

作　　者：何平[1] 刘全忠[1] 

机构地区：[1]西华师范大学化学化工学院,四川南充637002

出　　处：《合成化学》2009年第2期222-225,229,共5页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(20772097)

摘　　要：在10 mol%三氟乙酸存在下,金鸡纳碱衍生的手性二胺(10 mol%)催化丙酮和α-酮酸酯的A ldol反应,合成了一系列三级醇,产率99%,对映选择性93%。其结构经1H NMR表征。A series of third alcohol were synthesized by the Aldol reactions of α-keto acid esters with acetone in the presence of 10 mol% trifluoroacetie acid in up to 99% yield with up to 93%e. e.. The structures were confirmed by ^1 H NMR.

关 键 词：ALDOL反应 金鸡纳碱 α-酮酸酯 催化剂 

分 类 号：O621.25[理学—有机化学] O643.36[理学—化学]