氨基葡萄糖分散片的实验研究  

Study on Formulation and Quality Control of Glucosamine Dispersion Tablets.

作　　者：孙彦甫[1] 张俊 石涛[1] 缪玉山[1] 

机构地区：[1]东南大学附属中大医院药剂科,南京210009 [2]南京小市社区卫生服务中心药剂科,南京210037

出　　处：《中国医药导刊》2009年第1期157-158,共2页Chinese Journal of Medicinal Guide

摘　　要：目的:探讨氨基葡萄糖分散片的处方与质量控制方法。方法:以微晶纤维素(pH-301)、交联羧甲基纤维素钠、低取代羟丙基维素、微粉硅胶为辅料制备;采用紫外可见分光光度法测定其含量。结果:本处方制备的氨基葡萄糖分散片在光照(4500L×)、高温(60℃)、高湿(92.5%RH)10d及室温留样考察12mo,物理及化学性质稳定。结论:研制的氨基葡萄糖分散片性质稳定;质量控制方法准确可靠。Objective：To study on the formulation and quality control of glucosamine dispersion tablets. Methods： The glucosamine dispersion tablets with microcrystalline cellulose（pH301）,croscarmellose sodium,lactose and colloidal silicon dioxide as subsidiary material,the contents of glucosamine was performed by UV spectrometery. Results： The physico-chemical stability was good after storing 10d under illumination（4500Lx）,40℃,92.5% relative humidity（92.5%RH） and 12 mo under indoor temperature（25℃±2℃,60%±10% RH）. Conclusion： The selected formulation is good and can contribute to the development of the product. The method of quality control was reliable.

关 键 词：氨基葡萄糖 分散片 处方 质量控制 

分 类 号：R286[医药卫生—中药学]