丹参对兔Ⅱ度烧伤创面皮肤活力的影响  

EXPERIMENTAL STUDY OF THE EFFECT OF DANSHEN ON THE VIABILITY OF BURNED SKIN

作　　者：胡俊勇[1] 任林森[1] 

机构地区：[1]华西医科大学附属第一医院整形烧伤科

出　　处：《中国修复重建外科杂志》1998年第4期205-208,共4页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：为研究丹参对Ⅱ度烧伤创面皮肤活力的影响，探讨其对创面愈合的作用，以２０只日本大耳白兔制成Ⅱ度烧伤模型，分为丹参治疗组和对照组，对创面组织琥珀酸脱氢酶活性、过氧化脂质含量、含水量及组织形态学进行了动态观测。结果发现，治疗组琥珀酸脱氢酶活性高于对照组，在受伤８小时以后的各时间点两者均有显著差异（Ｐ＜０．０５）；而创面过氧化脂质含量及含水量治疗组低于对照组，在伤后８，２４及４８小时两组均有显著差异；组织学观察治疗组创面愈合过程优于对照组。认为，丹参有助于保护烧伤创面残存的上皮细胞。In order to investigate the influence of Danshen on the viability of skin from Ⅱ° burned and the effect of Danshen on the wound healing, 20 rabbits having a wound from second degree burn were divided into two groups randomly. The experimental group was treated with Danshen and the control was treated with normal saline. Then succinate dehydrogenase, SDH activity, malonyl dialdehyde, MDA concentration, water content and morphological change of wound tissue were observed dynamically. The results showed that the levels of SDH activity in the experimental group were significantly higher than that of the control group (P<0.05), the MDA concentration and water content of the former were lower than that of the latter (P<0.05) and the morphological examination showed that the wound healing process of former were better than that of the latter. The conclusion was Danshen had a beneficial effect on the viability of the burned skin and this effect was due to its protecting the residual epithelial cells of the burned skin.

关 键 词：丹参 烧伤 创面愈合 皮肤活力 中医药疗法 

分 类 号：R285.5[医药卫生—中药学] R269.440.5[医药卫生—中医学]