苯甲酰脲类化合物的合成及杀虫活性  

Synthesis and Insecticidal Activity of Benzoylphenylurea Derivatives

作　　者：张文文[1] 郑震[1] 彭延庆[1] 徐晓勇[1] 李忠[1] 

机构地区：[1]上海市化学生物学重点实验室,华东理工大学药学院,上海200237

出　　处：《农药学学报》2009年第1期36-40,共5页Chinese Journal of Pesticide Science

基　　金：国家自然科学基金(20502006,2087203);上海市科委和教委资助项目(073919107,064319022,B507)

摘　　要：对2-氨基-5-芳基-1,3,4口-恶二唑的合成进行了深入研究,找到了一种基于HBr-H2O2体系的绿色合成新方法,并以此为中间体,合成了18个未见报道的苯甲酰脲类目标化合物,所有化合物均通过核磁共振、高分辨质谱、红外光谱的分析鉴定。生物活性测试结果表明,在500mg/L浓度下该系列目标化合物均未表现出显著的杀虫活性。A cleaner approach to 2-amino-5-aryl-1,3,4-oxadiazoles,a series of benzoylphenylurea intermediates were developed and optimized by using HBr-H2O2 system as an alternative to molecular bromine.Eighteen novel benzoylphenylurea compounds were synthesized starting from 2-amino-5-aryl-1,3,4-oxadiazoles,and were identified by ^1H NMR,HRMS and IR spectra.However,no remarkable insecticidal activity was observed during bioassay.

关 键 词：HBr—H2O2溴代体系 绿色合成 苯甲酰脲 昆虫生长调节剂 

分 类 号：TQ252[化学工程—有机化工] O625.525[理学—有机化学]