DNA splice site sequences clustering method for conservativeness analysis  

作　　者：Quanwei Zhang, Qinke Peng, Tao Xu State Key Laboratory for Manufacturing Systems Engineering, School of Electronic and Information Engineering, Xi’an Jiaotong University, Xi’an 710049, China 

出　　处：《Progress in Natural Science:Materials International》2009年第4期511-516,共6页自然科学进展·国际材料（英文版）

基　　金：supported bythe National Natural Science Foundation of China (Grant Nos. 60373107 and 60774086)

摘　　要：DNA sequences that are near to splice sites have remarkable conservativeness, and many researchers have contributed to the prediction of splice site. In order to mine the underlying biological knowledge, we analyze the conservativeness of DNA splice site adjacent sequences by clustering. Firstly, we propose a kind of DNA splice site sequences clustering method which is based on DBSCAN, and use four kinds of dissimilarity calculating methods. Then, we analyze the conservative feature of the clustering results and the experimental data set.DNA sequences that are near to splice sites have remarkable conservativeness, and many researchers have contributed to the prediction of splice site. In order to mine the underlying biological knowledge, we analyze the conservativeness of DNA splice site adjacent sequences by clustering. Firstly, we propose a kind of DNA splice site sequences clustering method which is based on DBSCAN, and use four kinds of dissimilarity calculating methods. Then, we analyze the conservative feature of the clustering results and the experimental data set.

关 键 词：Bioinformatics processing CLUSTERING DBSCAN Splice site 

分 类 号：Q78[生物学—分子生物学]