不同类型心力衰竭患者治疗前后SOD与红细胞内外相关微量元素的变化  

Changes of superoxide dismutase and trace elements in different types of heart failures

作　　者：蔡春[1] 常耀明[2] 高双斌[3] 王伯良[4] 

机构地区：[1]第四军医大学西京医院预防保健科,陕西西安710032 [2]第四军医大学航空航天医学系,陕西西安710032 [3]第四军医大学预防医学系营养与食品卫生学教研室,陕西西安710032 [4]第四军医大学唐都医院急诊科,陕西西安710032

出　　处：《心脏杂志》2009年第2期242-243,247,共3页Chinese Heart Journal

基　　金：唐都医院院级课题资助(院研9028)

摘　　要：目的了解充血与缺血性心力衰竭(HF)时超氧化物歧化酶(SOD)及其相关微量元素细胞内外变化特征,为HF患者微量元素治疗提供依据。方法用放射免疫法测定27例急诊HF患者维生素C抗氧化治疗前后血清SOD,用日立180-80原子吸收分光光度计测定血浆及红细胞内外微量元素Cu,Zn,Se,Fe。结果充血性HF(CHF)与缺血性心脏病伴心功能不全患者[缺血性HF(IHF)]及二者与正常组比较SOD均无显著差异。CHF治疗前后红细胞Se,Fe,Cu与正常组比较差异显著(P<0.01),治疗前后血浆Zn降低、Cu升高,与正常组比较差异显著(P<0.01)。治疗前血浆Se与正常组比较降低且有显著差异(P<0.05)。IHF治疗前后红细胞Se,Fe,Cu与正常组比较均降低且差异显著(P<0.01),治疗前后血浆Cu升高、Zn降低,与正常组比较差异显著(P<0.01)。IHF红细胞治疗后较治疗前Cu升高、Zn降低(均P<0.05)。IHF治疗前血浆Cu低于CHF组(P<0.05)。结论经维生素C抗氧化治疗血清SOD水平可接近正常水平,但危重HF患者与SOD相关微量元素代谢明显紊乱,尚需根据CHF与IHF不同特征补充微量元素。AIM To investigate the changes of superoxide dismutase （SOD） and trace elements in patients with congestive heart failure （CHF） or ischemic heart failure （IHF） before and after vitamin C treatment. METHODS Blood SOD and trace element levels were analyzed in 27 cases of emergence CHF and IHC subjects and the results were compared before and after vitamin C treatment. RESULTS No significant difference in serum SOD levels was observed between CHF and IHF. CHF group had much lower Se, Fe, and Ca in red blood ceils compared to those in normal subjects （P 〈0.01 ）. Plasma levels of Cu, Zn, Se had significant difference compared with those in normal subjects （P 〈 0. 05, P 〈 0. 01 ） before and after vitamin C treatment. In IHF group, So, Fe, Cu levels of red blood cell were significant lower than those in nomlal subject （P 〈0. 01 ） and significant difference was found in the plasma levels of Cu and Zu compared with those in normal subjects （P 〈 0. 01 ） before and after vitamin C treatment. Cu and Zu in red blood cell were significantly increased and decreased post-treatment （p 〈0, 05）. CONCLUSION SOD level can be maintained close to normal after vitamin C treatment in patients with CHF or IHF. Trace element supplement should be provided for disorder of SOD-related trace element in patients with serious heart failure.

关 键 词：心力衰竭 超氧化物歧化酶 微量元素 

分 类 号：R541.61[医药卫生—心血管疾病]