四针状氧化锌晶须对复合树脂抗菌性能的影响  

Effects of tetrapod-like zinc oxide whiskers incorporation on antibacterial activity of composite resin

作　　者：牛丽娜[1] 陈吉华[1] 方明[1] 杨聚才[2] 焦凯[3] 

机构地区：[1]第四军医大学口腔医学院修复科,西安710032 [2]第四军医大学口腔医学院检验科,西安710032 [3]第四军医大学口腔医学院解剖生理教研室,西安710032

出　　处：《中华口腔医学杂志》2009年第4期240-242,共3页Chinese Journal of Stomatology

基　　金：陕西省科技计划（2008K11-02）

摘　　要：目的研究四针状氧化锌晶须（tetrapod—like zinc oxide whiskers，T—ZnOw）抗芮剂对复合树脂抗菌性能的影响，为减少树脂修复后继发龋提供新方法。方法液体稀释法测试T-ZnOw和无机载银抗菌剂对变形链球菌的最小抑菌浓度（minimal inhibitory concentration，MIC）及最小杀菌浓度（minimal bactericidal concentration，MBC）。复合树脂粉剂中分别加入质量分数为3％、5％、10％的T—ZnOw和质量分数分别为1％、3％、5％的无机载银抗菌剂，直接接触法测定抗菌率，比较树脂样本加速老化处理3个月后的抗菌率。结果T—ZnOw和无机载银抗菌剂的MIC分别为0．15625、0．15625g／L，MBC分别为0．3125、0．15625g／L。T—ZnOw质量分数为3％、5％、10％时，树脂对变形链球菌的抗菌率分别为（84．85±5．16）％、（94．22±3．73）％、（99．43±0．48）％。无机载银抗菌剂质量分数为1％、3％、5％时，复合树脂的抗菌率分别为（71．014-7．67）％、（90．76±5．91）％、（97．19±4．10）％。老化后添加5％T—ZnOw和5％无机载银抗菌剂的树脂抗菌率分别为（89．89±5．55）％和（78．79±7．81）％。结论添加T—ZnOw町赋予复合树脂抗菌性能，其质量分数达5％时即可取得较好的抗菌效果，且抗菌长效性优于无机载银抗菌剂。Objective To evaluate effects of incorporating tetrapod-like zinc oxide whisker （T-ZnOw） antibacterial agent on the antibacterial activity of composite resin, compared with that of the silver-based inorganic antibacterial agent. Methods The minimal inhibitory concentration （MIC） and minimal bactericidal concentration （MBC） of the two different antibacterial agents against Streptococcus mutans were investigated using the broth dilution test. Then the antibacterial activities of the self-cured composite resin specimens with different incorporating concentrations of the two antibacterial agents were evaluated using direct contact test. And the antibacterial activities of the resin specimens were examined again after 3 months of accelerating aging. Results The MIC （MBC） of the T-ZnOw antibacterial agent and silver-based inorganic antibacterial agent were 0. 15625 （0. 3125 ） g/L and 0. 15625 （0. 15625 ） g/L. When the concentrations of T-ZnOw added to composite resin were 3% , 5% , and 10% （w/w） , the antibacterial ratios of the resin specimens were （84.85 ± 5.16）%, （94.22 ±3.73）%, and （99.43 ±0.48）% respectively. When the concentrations of the silver-based antibacterial agent added to composite resin were 1%, 3% , and 5%, the antibacterial ratios were （71.01 ± 7.67 ）%, （90.76 ± 5.91 ）%, and （97. 19 ± 4. 10）% respectively. The antibacterial ratios of the resin specimens containing 5% of both antibacterial agents were （89. 89±5.55）% and （78.79 ±7.81 ）% respectively after 3 months of accelerating aging. Conclusions Incorporation of the T-ZnOw antibacterial agent in composite resin can improve the antibacterial performance of the resin, and the resin exhibits better antibacterial performance than that incorporating silver-based inorganic antibacterial agent after 3 months of aging.

关 键 词：复合树脂类 四针状氧化锌晶须 无机载银抗菌剂 抗菌性 

分 类 号：R686[医药卫生—骨科学]