山黄肝脂康颗粒抗肝纤维化作用的研究  

Study of Shanhuang-ganzhikang Granule on the Rats of Liver Fibrosis

作　　者：贺彬[1] 张裕民[2] 

机构地区：[1]益阳市人民医院,湖南益阳413001 [2]湖南中医药大学第一附属医院,湖南长沙410007

出　　处：《中医药导报》2009年第3期72-74,共3页Guiding Journal of Traditional Chinese Medicine and Pharmacy

摘　　要：目的:探讨山黄肝脂康颗粒对CCl4致大鼠肝纤维化的作用及其机理。方法:将50只大鼠随机分为空白组,模型组,山黄肝脂康颗粒低剂量组和高剂量组,大黄蟅虫丸组共5组,除空白组外,其余各组采用CCl4造肝纤维化模型,实验结束检测各组动物的肝功能和肝纤维化指标,观察肝组织病理学变化。结果:山黄肝脂康颗粒低剂量组和高剂量组以及大黄蟅虫丸组均可使大鼠血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)的活性降低,白蛋白的含量升高;同时也可降低血清中透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、ⅣC型胶原(ⅣC)及层粘连蛋白(LN)的含量。结论:山黄肝脂康颗粒具有较好的抗肝纤维化的作用。Objective：To investigate the effects of Shanhuang-ganzhikang Granule on the rat of liver fibrosis induced by CCh .Methods： 50 rats were divided into five group（control group, model group, Shanhuang-ganzhikang Granule low and high dose group, Dahuangzecong Wan group） randomly. On the end, the indexes of liver function and liver fibrosis were examined , meanwhile, the liver tissue of pathology were observed. Results： ALT and AST were decreased in low and high dose group and the content of ALB were increased. At the same time, the content of HA,PCⅢ, ⅣC,LN were decreased. Conclusion： There are good effects of Shanhuang-ganzhikang Granule on liver fibrosis.

关 键 词：山黄肝脂康颗粒 肝纤维化 实验研究 

分 类 号：R248.5[医药卫生—中医临床基础]