KLOTHO基因C-1818T多态性与老年急性冠脉综合征的关联研究  

KLOTHO gene C - 1818T polyrnorphism in elderly patients with acute coronary syndrome

作　　者：何国平[1] 金鸣锋[1] 高磊[1] 杨进[2] 王俊宏[2] 沈丽娟[1] 戚传平[1] 杨国英[1] 杨笛[2] 张寄南[2] 

机构地区：[1]江苏大学附属武进医院,江苏213002 [2]江苏省人民医院,江苏210000

出　　处：《常州实用医学》2009年第1期3-6,共4页CHANGZHOU PRACTICAL MEDICINE

摘　　要：目的观察中国苏皖地区汉族老年（≥60岁）人群KLOTHO基因第四外显子C-1818T多态性分布，探讨其与老年人急性冠脉综合征（acute coronary syndrome，ACS）的可能关系。方法采用聚合酶链反应（polymerase chain reaction，PCR）及基因芯片（gene mieroarray）技术，检测272例老年ACS患者（ACS组）和139例老年非冠心病者（对照组）的KLOTHO基因C-1818T多态性。结果与对照组相比，ACS组CC、TT基因型以及T等位基因型频率分布无显著差异，CT基因型频率明显升高（P=0．031）。经多元logistie回归并调整相关危险因素后发现，CT基因型与老年人特别是老年男性ACS的发病相关联。结论在中国苏皖地区汉族老年人群（特别是老年男性）中，KIDTHO基因C-1818T多态性CT基因型与ACS的发病存在相关性。Objective To study the distribution of KLOTHO gene C - 1818T polymorphism in the Chinese Han population of Suwan region and to explore the possible association of the KLOTHO gene C - 1818T polymorphism with acute coronary syndrome（ACS）in the elderly（ age ≥ 60 years）.Methods This study was conducted with a ease - control design including 272 patients with ACS（ACS group）and 139 control subjects who were free from coronary artery disease through coherence checks（control gsoup）. The KLOTHO gene C- 1818T polymorphism was determined by polymerase chain reaction（PCR）and gene mieroarray. Results Compaired with the control group, The frequencies of CC, TT genotype and the T allele of the C - 1818T in ACS group was not significantly different,but the prevalence of the CT genetype in elderly patients of ACS group was obveriously higher（ P = 0.031）. After adjustment for conventional risk factors by multiple logistic regression analysis, the carrier prevalence of the CT genetype was still differ significantly between the elderly,especially in elderly male patients with ACS and control subjects. Conclusion The cr genetype of KLOTHO gene C - 1818T polymorphism was associated with the susceptibility to ACS in the elderly, especially in elderly male, in the Chinese Hart population of Suwan region.

关 键 词：KLOTHO 基因多态性 急性冠脉综合征 

分 类 号：R339.38[医药卫生—人体生理学] R541.4[医药卫生—基础医学]