雄激素受体对前列腺癌细胞侵袭转移能力的影响及其意义  

Role of androgen receptor on the invasion/metastasis ability of PC3 cells and its clinical significance

作　　者：于胜强[1] 史本康[2] 

机构地区：[1]上海交通大学附属第一人民医院,上海200080 [2]山东大学齐鲁医院

出　　处：《山东医药》2009年第14期25-26,共2页Shandong Medical Journal

基　　金：国家自然科学基金资助项目(30672109)

摘　　要：目的研究雄激素受体(AR)对雄激素非依赖性前列腺癌细胞株PC3侵袭转移能力的影响及意义。方法应用肿瘤细胞侵袭实验、创伤愈合实验以及软琼脂糖凝胶实验检测AR对PC3侵袭转移能力的影响。结果外源性AR转染到PC3(PC3-AR)后,其侵袭能力明显减弱,创伤愈合能力降低,在琼脂糖凝胶中形成克隆能力降低。结论AR明显降低雄激素非依赖性PC3的侵袭转移能力。Objective To investigate the role of androgen receptor（AR） on the invasion/metastasis ability of androgen-independent prostate cancer cell line PC3 in vitro and its clinical significance. Methods The chamber invasion assay, wound healing assay, and colony formation assay were performed to observe the AR effect on PC3 cells＇ invasion/metastasis ability. Results Restoring AR in PC3 cells resulted in decreased invasion^metastasis ability in chamber invasion assay, wound healing assay and colony formation assay. Conclusions The AR functions as a suppressor in the invasion/metastasis ability of the hormone refractory prostate cancer cell line PC3.

关 键 词：雄激素受体 前列腺肿瘤 PC3 侵袭力 

分 类 号：R697.3[医药卫生—泌尿科学]