微分脉冲伏安法测定药物中盐酸去氧肾上腺素的含量  

Differential Pulse Stripping Voltammertric Determination of Phenylehrine Hydrochloride Using Glassy Carbon Electrode

作　　者：倪永年[1,2] 桂怿[2] 

机构地区：[1]南昌大学食品科学与技术国家重点实验室,江西南昌330047 [2]南昌大学化学系,江西南昌330031

出　　处：《南昌大学学报（理科版）》2009年第1期35-37,共3页Journal of Nanchang University(Natural Science)

基　　金：国家自然科学基金资助项目(20562009);江西省自然科学基金资助项目(0620041);中科院长春应化所电分析化学重点实验室基金资助项目(SKLEAC2004-3);南昌大学食品科学与技术国家重点实验室(SKLF-MB-200807;SKLF-TS-200819);长江学者及创新团队基金资助项目(IRT0540)

摘　　要：应用微分脉冲伏安法研究了盐酸去氧肾上腺素在玻碳电极上的电化学行为及其测定方法。在pH 9.62的B ritton-Rob inson缓冲液中,盐酸去氧肾上腺素在E=350 mV处具有良好的电化学氧化峰,线性范围为0.1-1μg.mL^-1,检出限为0.033μg.mL^-1,利用该方法对针剂样品中的盐酸去氧肾上腺素进行直接测定。获得了较好的定量分析结果。A differential pulse voltammetry method for the determination of penylephrine hydrochloride has been studied.The electrochemical behavior and voltammetric parameters of phenylephrine hydrochloride at a glass carbon electrode were investigated and evaluated.In the Britton-Robinson（B-R） buffer,phenylephrine hydrochloride has an irreversible oxidative peak at the potential of 350 mV and the peak current was linear with its concentrations in the range of 0.1~1.0 /μg·mL-1.The detection limit was 0.033 /μg·mL-1.The proposed method is simple and easy to operation.The proposed was applied to the determination of penylephrine hydrochloride in several drugs samples with satisfactory results.

关 键 词：盐酸去氧肾上腺素 微分脉冲溶出伏安法 电化学 

分 类 号：O657.1[理学—分析化学]