新蝶呤和IL-8水平与冠心病患者冠脉病变稳定性及狭窄程度关系  

The Relationship between Levels of Neopterin,IL-8 and Stability of Lesions,Severity of Coronary Stenosis in Patients with Coronary Heart Disease

作　　者：王钢[1] 赵荣诚[1] 韩佳[1] 

机构地区：[1]河北省沧州市中心医院心内一科,沧州061001

出　　处：《中国医药导刊》2009年第2期177-179,共3页Chinese Journal of Medicinal Guide

摘　　要：目的:研究新蝶呤(Npt)和自细胞介素-8(IL-8)与冠心病患者冠脉病变稳定性及病变狭窄程度的关系。方法:对60例心绞痛患者,其中不稳定型心绞痛(UAP)30例,稳定型心绞痛(SAP)30例,另20例正常对照,以酶联免疫法测定Npt,IL-8水平,均接受冠状动脉造影,根据冠状动脉造影结果,分为对照组、单支病变组、双支病变组、三支病变组,并根据冠状动脉狭窄程度及部位进行记分。结果:与SAP患者相比,Npt[(19.83±8.58)∶(12.50±5.34)μg/L,P<0.05]、IL-[(101.93±21.43)∶(69.81±20.15)pg/ml,P<0.05]在UAP患者中明显升高,两组均显著高于对照组(P<0.05)。三支病变组Npt、IL-8水平显著高于双支病变组和单支病变组,三组均高于对照组。三组之间有统计学差异。多元回归分析表明,Npt、IL-8是UAP和冠状动脉狭窄程度的独立危险因素。结论:Npt和IL-8可作为判定冠心病患者冠状动脉病变稳定性和狭窄程度的指标。Objective： To investigate the relationship between Npt, IL-8 and stability of coronary lesions, severity of coronary stenosis. Methods ： Npt and IL-8 level were measured with ELISA in 80 patients,including UAP 30, SAP 30 and normal 20. All patients with coronary angiography. Results：IL-8,Npt were elevated in unstable angina group than those in stable angina group, IL-8 [ （101.93±21.43 ）： （69. 81 ± 20. 15 ） pg/ml, P 〈 0.05 ], Npt [ （ 19. 83 ± 8.58 ） ： （ 12. 50 ± 5.34 ） μg/L, P 〈 0, 05 ], and they were significantly higher than those in control group. The levels of Npt, I[,-8 in patients with triple-vessel or double-vessel lesions were higher than those with single-vessel lesions, and they were significantly higher than those in control group. Multiple regression analysis＇of Logistic indicated that Npt, IL-8 were independent risks for the stability of lesions and the severity of stenosis in patients with Coronary Heart Disease. Conclusions ： Npi and IL-8 might be the predictors of stability and severity in coronary lesions.

关 键 词：心绞痛 新蝶呤 白细胞介素-8 冠脉狭窄积分 

分 类 号：R541.4[医药卫生—心血管疾病]