国产顺式阿曲库铵用于梗阻性肾病患者麻醉的药效学观察  

Pharmacodynamics of Cisatracurium in Patients of Obstructive nephropathy

作　　者：唐正国[1] 常业恬[1] 杨隆秋[1] 

机构地区：[1]中南大学湘雅二医院麻醉科,湖南长沙410011

出　　处：《医学临床研究》2009年第3期430-431,434,共3页Journal of Clinical Research

摘　　要：【目的】观察非去极化肌松药顺式阿曲库铵用于梗阻性肾病患者麻醉中的肌松效应。【方法】18倒梗阻性骨病患者行单侧肾脏或输尿管切开取石术，随机分为顺式阿曲库铵Ⅰ组（2倍ED95组）、Ⅱ组（3倍ED95组），对照组为18例行腹部手术患者随机分为顺式阿曲库铵Ⅲ组（2倍ED95组）、Ⅳ组（3倍ED95组）。观察患者气管插管条件、肌松效应。【结果】Ⅰ、Ⅲ组插管条件为优的比率明显低于Ⅱ、Ⅳ组（P〈0．05）；Ⅰ组、Ⅲ组起效时间大于Ⅱ组、Ⅳ组，但是T175％恢复时间、TOF比值恢复到70％的时间明显短于Ⅱ组、Ⅳ组（P〈0．05）。【结论】3倍ED95剂量的顺式阿曲库铵比2倍ED95剂量起效更快，插管条件更好；能安全应用于肾功能障碍患者。[Objective]To study the pharmacodynamic profiles of cisatracurium in patients of obstructive nephropathy. [Methods] Eighteen patients of obstructive nephropathy undergoing one-side nephrolithotomy or ureterolithotomy were randomized into group Ⅰ （2ED95） and group Ⅱ （3ED95）. As control, 18 patients undergoing abdominal surgery were randomized to group Ⅲ （2ED95） and group Ⅳ （3ED95）. The intubation conditions and muscle relaxant effects were observed. [Results] Group Ⅰ and Ⅲ for the excellent intubation conditions were significantly lower than those of group Ⅱ and Ⅳ（ P 〈0.05）. Onset time of group Ⅰ and Ⅲ were longer than that of groupⅡ and Ⅳ, while T1 75% recovery time and the time of TOF ratio back to 70% were significantly shorter than those of group Ⅲ and Ⅳ（ P 〈0.05）. [Conclusion] Onset time of 3ED95 dose of cisatracurium is faster than 2ED95 dose, and its intubation conditions are better . Cisatracurium can be safely used in patients with renal dysfunction.

关 键 词：梗塞 肾疾病/外科学 麻醉 阿曲库铵/治疗应用 

分 类 号：R692[医药卫生—泌尿科学]