血液灌注加血液透析联合治疗对β2-MG及PTH的清除作用  

Clinical Study on the Effect of Hybrid Artificial Kidney and Other Blood Purification Methods on β2-microglobulin and Parathyroid Hormone （PTH） Levels in Patients on Maintenance Hemodialysis

作　　者：臧翠平 周巧玲[2] 许辉[2] 龙敏琦 刘湘华 

机构地区：[1]湖南省株洲市二医院肾内科,湖南株洲412000 [2]中南大学湘雅医院肾内科,湖南长沙410008

出　　处：《医学临床研究》2009年第3期477-478,481,共3页Journal of Clinical Research

摘　　要：【目的】探讨血液灌注＋血液透析与其它血液净化方式对血清β2-微球蛋白（β2MG）和甲状旁腺激素（PTH）的清除效果。【方法】将72例维持性血液透析患者随机分为三组：血液灌流＋血液透析（HDP）组、血液透析（HD）组和血液透析滤过（HDF）组，比较三组单次治疗对血清β2--MG和PTH的清除率。【结果】①HD组、HDF组和HDP组均能有效清除血清尿素氮（BUN）、肌酐（Scr）和血磷（P〈0．01）。②HDP组与HDF组治疗前后血清β2-MG和PTH均显著下降（P〈0．01），HD组治疗前后血清β2-MG和PTH均无显著下降（P〉0．05）；③HDP组与HDF组对β2-MG和PTH的清除率比较差异无显著性（P〉0．05），此两组的清除率与HD组比较差异均有显著性（P〈0．01）。【结论】HDP与HDF可有效清除β2-MG及PTH；HD不能有效清除β2-MG及PTH。[Objective] To compare the clearance effects of different blood purification methods on β2 microglobulin and parathyroid hormone （PTH） levels in patients on maintenance hemodialysis（HD）. [Methods] Seventy two patients on maintenance hemodialysis were randomly divided into hemodiafihration group （HDF） , hemoperfusion plus hemodialysis group（HDP） and hemodialysis group（HD）. Serum PTH and β2-microglobulin levels were observed before and after single treatment. [Results] In HDF and HDP group, PTH and β2-microglobulin were decreased significantly （ P 〈0.05）. The difference between HDF and HDP was not significant （ P 〉0.05）. After HD treatment, serum PTH and β2-microglobulin were not decreased （ P 〉0.05）. [Conclusion] Hemodiafiltration or hemoperfusion plus hemodialysis can safely and effectively clear serum β2 microglobulin and PTH, while hemodialysis can not effect the level of serum β2-microglobulin and PTH.

关 键 词：血液灌注 血液透析 Β2微球蛋白 甲状旁腺激素类 

分 类 号：R459.5[医药卫生—治疗学]