利用电荷迁移反应测定头孢羟氨苄  

Spectrophotometric Determination of Cefadroxil Using Its Charge-transfer Reaction

作　　者：陈学诚[1] 董文庚[1] 郎志敏[1] 赵庆雪 胡俊玲 容彦华[2] 刘辉 冯美卿 

机构地区：[1]河北科技大学环境工程系,石家庄050018 [2]石家庄第一制药厂,石家庄050051

出　　处：《分析化学》1998年第3期310-313,共4页Chinese Journal of Analytical Chemistry

摘　　要：提出一种基于电荷迁移反应简便可靠地测定头孢羟氨苄的分光光度法。在甲醇－乙醇介质中，头孢羟氨苄与氯冉酸于５０℃反应１５ｍｉｎ能够形成稳定的１：１络合物，其λｍａｘ＝５２８ｎｍ，线性范围为２０～４００ｍｇ／Ｌ。用拟定的方法测定原粉和胶囊，结果与药典法一致。对浓度１００ｍｇ／Ｌ的药物１０次测定相对标准偏差为１．４％，样品的标准加入回收率为９９．０％～１００．８％。A simple and reliable spectrophotometric method for the determination of cefadroxil has been developed based on the charge-transfer reaction. Cefadroxil is reacted with chloranilic acid in a mixture of methanol and ethanol at 50℃ for 15 min and a rose complex is formed. Experiment shows that the maxium absorption of the complex is at 528 nm and the molar ratio of cefadroxil and chloranilic acid is l:1. The linear range of the determination is 20-400 mg/L. The proposed method has been applied to the analysis of cefadroxil pharmaceutical raw material powder and capsules with satisfactory results. The recoveries are 99.0% ~ 100.8%. The relative standard deviation is 1.4%(n=10).

关 键 词：电荷迁移反应 头孢羟氨苄 氯冉酸 光度法 

分 类 号：R978.11[医药卫生—药品]