大鼠口服朱砂的毒代动力学研究  

Toxicokinetics of mercury after oral administration of cinnabar in rats

作　　者：杨堃[1] 李秀芳[1] 孙艳[2] 陈丽平[2] 吴永会[3] 丁国华[2] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江省第二医院暨黑龙江省中毒抢救治疗中心,黑龙江哈尔滨150010 [3]哈尔滨医科大学,黑龙江哈尔滨150081

出　　处：《中国医院药学杂志》2009年第7期534-537,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的:研究朱砂单次和连续大剂量给药后汞在大鼠血液的毒代动力学规律及其血液蓄积性。方法:大鼠单次或连续口服朱砂(7.0g·kg-1)后采集血液样品,微波消解-原子荧光光谱法测定全血中汞浓度,绘制药时曲线并计算毒代动力学参数。结果:单次口服朱砂后汞在大鼠体内符合单室模型分布,主要毒代动力学参数:t1/2为6.64h,tmax为1.29h,Cmax为5.63μg·L-1,AUC为61.40μg·h·L-1;连续给药后第4天和第10天血中汞浓度有升高趋势,但未见显著差异。结论:口服朱砂后汞在大鼠体内消除缓慢,大剂量连续口服朱砂可能导致汞在全血中的蓄积。OBJECTIVE To find out the toxicokinetics and accumulation of mercury in blood after single and successive large dosage oral administration of cinnabar to rats. METHODS Each rat was given a 7. 0 g. kg^-1 dosage of cinnabar orally single or successive. The blood samples of rats were collected on time after dosed. Microwave digestion-atomic fluorescence spectrometry method was used to determine the concentration of mercury in blood. Time-course and toxicokinetics parameters of mercury in blood were analyzed. RESULTS Mercury showed single compartment model in rats and the main parameters of toxicokinet- ics were as follows： t1/2 6. 64 h, tmax1. 29 h, Cmax5. 63 μg·L^-1, AUC 61.40 μg·h·L^-1. After successive bolus oral administration of cinnabar to rats, blood concentrations of mercury achieved a higher level at the fourth day and the tenth day, but there were no significant difference （P〉0. 05） between the days after：successive large dosage. CONCLUSION These results sugges- ted the slow excretion of mercury in rats, and the possibility of accumulation of mercury in blood after successive large dose oral administration of cinnabar to rats.

关 键 词：朱砂 汞 全血 毒代动力学 蓄积 

分 类 号：R285.5[医药卫生—中药学]