BMI及血脂与原发性高血压基因多态性关系  

Association of leptin receptor gene mutation with BMI and serum lipid levels in hyperpietic population of China

作　　者：刘红[1] 高志东[2] 陈大方[1] 胡永华[1] 

机构地区：[1]北京大学医学部公共卫生学院流行病与卫生统计学系/流行病学教育部重点实验室,北京100083 [2]北京结核病控制研究所

出　　处：《中国公共卫生》2009年第4期451-453,共3页Chinese Journal of Public Health

基　　金：国家“973”计划项目(2006CB503903)

摘　　要：目的在原发性高血压人群中,探讨体质指数(BMI)和血脂水平与瘦素受体(LEPR)基因A223G突变关系。方法选取上海市黄浦区原发性高血压人群进行问卷调查、体检、生化指标和A223G突变的检测。结果902例原发性高血压患者中,体重正常组(BMI<24kg/m2)400例,超重肥胖组(BMI≥24kg/m2)502例,男性超重肥胖占59.3%,高于女性50.4%(P<0.01)。A223G基因型多态性分布:男性AA、AG、GG分别为2.8%,19.8%,77.4%;女性分别为4.9%,23.4%,71.7%。调整相关影响因素后,A223G多态性G等位基因与甘油三酯(TG)、甘油三酯/高密度脂蛋白比值(TG/HDL)水平升高以及HDL水平降低显著相关(P<0.05)。两因素间交互作用检验结果显示,A223G与超重及肥胖对原发性高血压患者的HDL水平降低存在交互作用关系,调整混杂因素后,交互作用系数95%CI=0.0～0.1(P=0.042)。结论LEPR基因A223G突变和血脂水平相关,并可调节超重及肥胖与HDL的关系。Objective To investigate the association of leptin receptor gene（LEPR） A223G polymorphism with BMI and serum lipid levels in hyperpietic population of China. Methods The subjects were collected in Huangpu district in Shanghai,China. All subjects were subjected to a standard questionnaire and physical examination. PCR-RFLP method was used to detect the genotypes of A223G mutation. Obesity was classified as BMI≥24 kg/m^2. Results Nine hundred and two hypertension sufferers were eligible for the analysis. TG and TG/HDL levels were significantly higher and HDL level was significantly lower in obesity group than those in normal body weight group（ P 〈 0. 05）. The interaction of A223G mutation genotype and obesity were statistically significant in HDL（95% CI = 0. 0 -0. 1, P = 0. 042）. Conclusion The results indicate that LEPR A223G mutation is associated with serum lipid levels and it can modulate the relationship between obesity and serum HDL level.

关 键 词：血脂 肥胖 瘦素受体 交互作用 

分 类 号：R589.2[医药卫生—内分泌]