慢性铅中毒性肾损害患者EDTA驱铅效果分析  

Curative effect of EDTA on kidney injury caused by chronic lead poisoning

作　　者：苏素花[1] 廖瑞庆[1] 农康[1] 葛宪民[1] 蒋东方[1] 韦国铭[1] 

机构地区：[1]广西壮族自治区职业病防治研究院中毒科,南宁530021

出　　处：《中国公共卫生》2009年第4期466-467,共2页Chinese Journal of Public Health

基　　金：广西自然科学基金(桂科基0236051)

摘　　要：目的探讨依地酸钙钠(EDTA)驱铅治疗慢性铅中毒患者肾损害的保护作用。方法对52例慢性轻度铅中毒者连续3年用EDTA驱铅治疗,并对其进行血铅(PbB)、红细胞锌卟啉(ZPP)、尿β2-微球蛋白(U-β2-MG)、尿视黄醇结合蛋白(U-RBP)、尿N-乙酰-β-D-氨基葡萄糖苷酶(U-NAG)监测。结果慢性铅中毒患者PbB、ZPP、U-β2-MG、U-NAG、U-RBP分别为(595.36±134.34)μg/L、(4.16±1.96)μmol/L、(564.02±224.32)μg/(g.Cr)、(31.91±13.37)U/(g.Cr)、(584.38±238.82)μg/(g.Cr)均显著高于对照组〔分别为(123.53±49.14)μg/L、(1.33±0.99)μmol/L、(139.26±66.62)μg/(g.Cr)、(11.83±3.7)U/(g.Cr)、(158.7±61.5)μg/(g.Cr)〕(P<0.01);连续3年用EDTA驱铅治疗后,U-β2-MG、U-NAG、U-RBP逐年下降,不同时间比较其检测结果差异有统计学意义(P<0.01)。结论用EDTA驱铅治疗可逆转慢性铅中毒患者的肾损害。Objective To study the protective effect of sodium calcium edetate（EDTA） on kidney injury in chronic lead poisoning patients. Methods The 52 chronic lead poisoning workers were treated with EDTA for 3 years. The blood lead （PhB） , erythrocyte zinc protoporphyrin （ZPP） , urine β2 -microglobulin （U-β2-MG） , urine retinal conjugated protein （U-RBP） , urine β-N-acetylyluco-samidase（U-NAG） of the workers were dynamically detected. Results All of the indices of poisoning worker were higher than that of control group before EDTA treatment （ P 〈 0.01 ）. After continuously treatment of EDTA, the values of the indices decreased year by year and the differences in the values between each year were significant（ P 〈 0. 01 ）. Conclusion The EDTA treatment is protective to the kidney injury in chronic lead poisoning patients.

关 键 词：慢性铅中毒 肾损害 依地酸钙钠(EDTA) 驱铅治疗 

分 类 号：R135.11[医药卫生—劳动卫生]