鸦胆子油乳对人卵巢癌耐药细胞A2780/DDP的耐药逆转作用  

Reverse Effect of Brucea Javanica Oil Emulsion on Drug Resistant Human Ovarian Carcinoma Cells A2780/DDP

作　　者：陈丹[1,2] 陈萍[1] 祝敏[1,2] 石小燕[1] 潘东风[1] 孔霞[1] 郑飞[1] 郭凌郧[1] 

机构地区：[1]郧阳医学院附属人民医院,十堰442000 [2]湖北中医学院,硕士生武汉430000

出　　处：《中国中医急症》2009年第4期598-599,共2页Journal of Emergency in Traditional Chinese Medicine

摘　　要：目的研究鸦胆子油乳对人卵巢癌耐药细胞A2780/DDP的耐药逆转作用。方法四甲基偶氮唑蓝(MTT)法观察顺铂及鸦胆子油乳对A2780/DDP细胞的生长抑制作用。结果卵巢癌耐药细胞株A2780/DDP对顺铂产生耐药性,顺铂对A2780/DDP的耐药倍数为5.6倍。经鸦胆子油乳预处理24h后,顺铂对A2780/DDP的耐药倍数显著下降。结论鸦胆子油乳可逆转卵巢癌耐药细胞A2780/DDP的耐药性。Objective： To study the reverse effect of brucea javanica oil emulsion on drug resistant human ovarian carcinoma cells A2780/ DDP. Methods： MTT assay was used to determine the lethal effect of DDP and brucea ja- vanica oil emulsion on A2780/DDP cells. Results： The human ovarian carcinoma cells A2780/ DDP showed drug resistance to DDP, and the resistance of A2780/ DDP cells to DDP was 5.6 times. After 24h precondition with brucea javanica oil emulsion, RI of DDP decreased significantly. Conclusion： Brucea javanica oil emulsion could reverse drug resistance of A2780/ DDP cells.

关 键 词：鸦胆子油乳 卵巢癌 耐药逆转剂 

分 类 号：R285.5[医药卫生—中药学]