血小板膜糖蛋白IaC807T多态性与阿司匹林抵抗的研究  

Study of Platelet Membrane Glycoprotein Ia Polymorphism C807T and Aspirin Resistance

作　　者：辛晓敏[1] 张云平[1] 金英玉[1] 李洁[1] 毕莉[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院检验科,哈尔滨150001

出　　处：《现代检验医学杂志》2009年第2期5-7,共3页Journal of Modern Laboratory Medicine

基　　金：黑龙江省重大攻关项目（No.GC05C40502）;黑龙江省教育厅课题（No.11531141）.

摘　　要：目的探讨血小板膜糖蛋白（GP）Ia基因C807T的多态性与患者发生阿司匹林抵抗的相关性.方法330例心脑血管病患者服用阿司匹林（100mg/d）至少7d以上，用二磷酸腺苷（adenosinediphosphate，ADP）和花生四烯酸（araehidonicacid，AA）作为诱导剂测定血小板聚集功能，找出阿司匹林抵抗（aspirinresistance，AR）患者，用PCR法确定血小板膜糖蛋白Ⅰa基因C807T的基因型.结果等位基因纯合子807（T/T）型和等位基因T在阿司匹林半抵抗与敏感人群中分布比较差并有统计学意义（P〈0．05）.结论血小板膜糖蛋白Ⅰa/Ⅱa的纯合子等位基因807T/T型与阿司匹林抵抗的发生相关，阿司匹林抵抗可能与遗传因素有关.Objective To investigate the associativity between platelet membrane glycoprotein Ⅰa/Ⅱa polymorphism C807T and aspirin resistance. Methods 330 stable cardiovascular and cerebrovascular diseases patients took aspirin（100mg/d for ≥7 days ）. Detected platelet aggregation function using adenosine diphosphate （ADP） and arachidonic acid （AA）. Genotyping of platelet membrane glycoprotein Ⅰa/Ⅱa C807T polymorphism was formed using a polymerase chain reaction analysis. Results The genotype 807（T/T） of aspirin semiresponders （ASR） were significantly different from aspirin sensitive（AS） patients （P〈0. 05）. Conclusion Platelet membrane glycoprotein Ⅰa/Ⅱa homozygote 807T/T is related to aspirin resistance. Aspirin resistance would be influenced by genetics.

关 键 词：阿司匹林抵抗 血小板聚集 糖蛋白Ia 基因多态 

分 类 号：R54[医药卫生—心血管疾病] Q786[医药卫生—内科学]