氯化钇和氯化镨引起的人淋巴细胞DNA分子损伤的研究  

A Study of DNA Damage in Human Lymphocytes Induced by Yttrium Chloride and Praseodymium Chloride

作　　者：杨辉[1] 嵇庆[1] 张锡然[1] 单祥年[2] 

机构地区：[1]南京师范大学生物系 [2]南京铁道医学院生物教研室

出　　处：《遗传》1998年第2期16-18,共3页Hereditas（Beijing)

摘　　要：用单细胞凝胶电泳法检测了稀土化合物氯化钇和氯化镨对人外周血淋巴细胞的ＤＮＡ损伤效应。结果表明，与对照相比，３种不同浓度的氯化钇和氯化镨均可引起淋巴细胞ＤＮＡ受损后ＤＮＡ迁移率的显著升高，受损伤细胞的百分率与对照差异明显，提示氯化钇和氯化镨具有一定的遗传毒性。The effect of DNA damage in human lymphocytes induced by yttrium chloride and praseodymium chloride was detected using SCG assay. The results showed that a highly significant increase in DNA migration in DNA-damaged lymphocytes was induced by three different concentrations ofyttrium and praseodymium compared with the control. The percentage of DNA-damaged lymphocytes was also increased. It is suggested that the rare-earth elements yttrium and praseodymium have genetic toxicity. The relevant points to this study are discussed

关 键 词：电泳 氯化钇 氯化镨 淋巴细胞 DNA损伤 

分 类 号：R992[医药卫生—毒理学] R995[医药卫生—药学]