国产199培养基制备狂犬病疫苗、乙型脑炎疫苗及麻疹疫苗的质量研究  

A Study On Quality Of Vaccine Prepared with Medium 199 Made in China

作　　者：吕宏亮[1] 邹勇[1] 吕亮 刘益荣 梁勇[1] 赵新华[1] 王亲民[1] 张春琴[1] 李根明[1] 

机构地区：[1]卫生部兰州生物制品研究所

出　　处：《微生物学免疫学进展》1998年第1期33-35,共3页Progress In Microbiology and Immunology

摘　　要：用国产１９９培养基，以进口１９９培养基和自配维持液为对照，制备狂犬病疫苗、乙型肝脑炎疫苗、麻疹疫苗。从这三种疫苗的毒力、效力、稳定性三个方面，比较国产１９９培养基作为疫苗维持液能否改进疫苗质量。试验结果表明：国产１９９培养基作为疫苗维持液制备这三种疫苗的质量和进口１９９培养基制备疫苗的质量几乎无差别，但优于自配维持液制备疫苗的质量。Medium 199 made in China are used to prepare three kinds of vaccines in the same condition,in contrast with medium 199 imported and Smmedium (Sm) prepared by our department.In this study,primary hamaster kindey cell inactivated Rabies (PHKC-IRV).Japenese encephalytis B vaccine (PHKC-JBV) and attenuated Measles vaccine(MV) are prepared with Medium 199 and Sm.Through comparing these vaccines quality target,including viral titer,virulence and potency,vaccine stability.we get a conclution that quality of vaccine manufactured with Medium 199 can be improved.

关 键 词：国产199培养基 效力 狂犬病 乙型脑炎 麻疹 疫苗 

分 类 号：R512.990.1[医药卫生—内科学] R512.320.1[医药卫生—临床医学]