暴露于次氟酸三氟甲酯后氟在豚鼠硬组织中的分布  

FLUORINE DISTRIBUTION IN BONES OF GUINEA PIGS AFTER EXPOSURE TO CF_3OF

作　　者：杨台春[1] 康忠玉[1] 张万友[1] 王泽甫[1] 詹承烈[2] 王宗全[2] 杨定焯[2] 孙昭瑞 

机构地区：[1]四川省劳动卫生职业病防治研究所,成都电信路19号610041 [2]华西医科大学卫生学院,成都人民南路3段17号610041 [3]四川省医学科学院,四川简阳市641400

出　　处：《工业卫生与职业病》1998年第2期69-73,共5页Industrial Health and Occupational Diseases

摘　　要：豚鼠暴露于次氟酸三氯甲酯（CF3OF）后，随着染毒浓度增高（0，0．13和2．02mg／m3）和染毒时间延长（2，6和10周），氟在硬组织中的含量明显增高，用显微密度仅测定见实验组骼骨密度明显增高。验证了长期接触有机氟气体可导致慢性中毒且影响骨骼的临床发现；肋和骼骨含氟量可能用作慢性有机氟中毒的诊断指标。It is well known that fluorine accumulated in tissues of bodies exposed to inorgano-fluorine couldcause fluorosis. Nevertheless,fluorine accumulation in bodies and significant increase in densities ofilium had also been observed in experimented guinea pigs exposed to CF3OF (Trifluoromethyl hy-pofluorite),one of organo-fluoride compounds. It is possible that chronic organo-fluorosis could becaused by long-term exposure to CF3OF. Fluorine contents in ribs and ilium could be associatedwith the diagnosis of occupational chronic organo-nuorosis.

关 键 词：氟分布 次氟酸三氟甲酯 硬组织 氟中毒 

分 类 号：R135.1[医药卫生—劳动卫生]